| http://purl.uniprot.org/citations/18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18339898 | http://www.w3.org/2000/01/rdf-schema#comment | "Stromal-derived factor-1 (SDF-1) and its receptor, CXCR4, are essential for normal hematopoietic progenitor cell movement and adherence within the bone marrow microenvironment. In leukemia, the BCR-ABL1 oncoprotein inhibits SDF-1-dependent cell trafficking within the bone marrow through a mechanism that is not fully understood. Here, we report that BCR-ABL1 in malignant cells constitutively increases expression of activation-dependent epitopes of the beta(2) integrin LFA-1. This is associated with the complete loss of responsiveness of LFA-1 to SDF-1-induced "inside-out" signaling involving CXCR4 and Lyn, leading to aberrant adhesive responses. These data provide a novel, LFA-1-mediated mechanism whereby BCR-ABL1 inhibits SDF-1 action in malignant progenitors."xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-10-117705"xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/author | "Chen Y.Y."xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/author | "Collman R.G."xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/author | "Malik M."xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/author | "Ptasznik A."xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/author | "Tomkowicz B.E."xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/pages | "5182-5186"xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/title | "BCR-ABL1 alters SDF-1alpha-mediated adhesive responses through the beta2 integrin LFA-1 in leukemia cells."xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/18339898 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18339898 |
| http://purl.uniprot.org/citations/18339898 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18339898 |
| http://purl.uniprot.org/uniprot/#_A0A023PX70-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |
| http://purl.uniprot.org/uniprot/#_A0A510LHF0-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |
| http://purl.uniprot.org/uniprot/#_A0A510LHH1-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |
| http://purl.uniprot.org/uniprot/#_A0A510LIH5-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5DI15-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |
| http://purl.uniprot.org/uniprot/#_A0A346G3H8-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |
| http://purl.uniprot.org/uniprot/#_C0LYZ4-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |
| http://purl.uniprot.org/uniprot/#_B2RAL6-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |
| http://purl.uniprot.org/uniprot/#_B4DQ77-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |
| http://purl.uniprot.org/uniprot/#_B4E021-mappedCitation-18339898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18339898 |