| http://purl.uniprot.org/citations/18340360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18340360 | http://www.w3.org/2000/01/rdf-schema#comment | "Birdshot chorioretinopathy (BCR), a chronic ocular inflammatory disease with characteristic choroidal lymphocytic infiltrates, has been strongly associated with human leukocyte antigen (HLA)-A29. Although HLA-A29 occurs frequently in all populations, BCR affects only a small percentage of HLA-A29-positive Caucasians, indicating additional susceptibility factors for BCR. Discovery of HLA class I-specific killer cell immunoglobulin-like receptors (KIR) led to a series of epidemiological studies implicating KIR-HLA gene combinations in disease. Here, we characterized KIR-HLA pairs in BCR patients and controls carrying HLA-A*29 as well as controls lacking HLA-A*29. KIR-HLA pairs implicated for weak inhibition (KIR2DL2/3+HLA-C1 and KIR3DL1+HLA-Bw4(T80)) in combination with activating KIR genes associated with autoimmunity (KIR2DS2, 2DS3 and 2DS4) augment the risk of developing BCR in HLA-A*29-positive individuals. The reciprocal association of strong inhibitory pairs (KIR3DL1+HLA-Bw4(I80) and KIR2DL1+HLA-C2) in combination with those implicated in protection from infection (KIR3DS1+HLA-Bw4(I80) and KIR2DS1+HLA-C2) was observed in HLA-A*29-negative controls. These results suggest that a profound effect of KIR2DS2/S3/S4 in the absence of strong inhibition may enhance the activation of natural killer cells and T-cell subsets against intraocular self-antigens, thereby contributing to pathogenesis of BCR."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.org/dc/terms/identifier | "doi:10.1038/gene.2008.13"xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Du Z."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Brezin A.P."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Reed E.F."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Cohen J.H."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Rajalingam R."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Tabary T."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Holland G.N."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Gjertson D.W."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Levinson R.D."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/author | "Monnet D."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/pages | "249-258"xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/title | "Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals."xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/18340360 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18340360 |
| http://purl.uniprot.org/citations/18340360 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18340360 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-18340360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18340360 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-18340360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18340360 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-18340360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18340360 |