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http://purl.uniprot.org/citations/18342927http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18342927http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Bcl-2 and Bcl-XL are the most important antiapoptotic members of the Bcl-2 family frequently overexpressed in bladder cancer. Overexpression of Bcl-XL bilharzial-related bladder cancer was associated with tumor progression. However, the negative prognostic value of Bcl-2 expression is still questionable. This work studied the expression of Bcl-XL and Bcl-2 immunohistochemically in bilharzial-related squamous cell carcinoma of the urinary bladder and determined their prognostic value in relation to recurrence after radical cystectomy.

Methods

A total of 72 patients with muscle-invasive bilharzial squamous cell carcinoma of the urinary bladder underwent radical cystectomy at our institution. The specimens were examined immunohistochemically for Bcl-XL and Bcl-2 expression. The patients were followed up for 3 years or until recurrence. The expression of Bcl-XL and Bcl-2 were related to the other prognostic indicators and patient survival.

Results

The expressions of both Bcl-2 and Bcl-XL were significantly different according to the grade of malignancy. Bcl-XL expression was significantly related to tumor recurrence, but Bcl-2 expression was not.

Conclusions

To our knowledge, the present study is the first report of a negative prognostic value for Bcl-XL in bilharzial squamous cell carcinoma of the urinary bladder. However, this is another negative report on the prognostic value of bcl-2 in bilharzial bladder tumors."xsd:string
http://purl.uniprot.org/citations/18342927http://purl.org/dc/terms/identifier"doi:10.1016/j.urology.2007.12.063"xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/author"Kamel N.A."xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/author"Abdel Aziz M.A."xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/author"Abdel Raheem A.M."xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/author"Hameed D.A."xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/author"Hammouda H.M."xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/author"Mosad E."xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/name"Urology"xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/pages"374-378"xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/title"Bcl-XL and Bcl-2 expression in bilharzial squamous cell carcinoma of the urinary bladder: which protein is prognostic?"xsd:string
http://purl.uniprot.org/citations/18342927http://purl.uniprot.org/core/volume"72"xsd:string
http://purl.uniprot.org/citations/18342927http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18342927
http://purl.uniprot.org/citations/18342927http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18342927
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http://purl.uniprot.org/uniprot/#_A0A1L4AQQ5-mappedCitation-18342927http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18342927
http://purl.uniprot.org/uniprot/#_A0A1L4AQQ8-mappedCitation-18342927http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18342927
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http://purl.uniprot.org/uniprot/#_A0A7I2V3S7-mappedCitation-18342927http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18342927
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