| http://purl.uniprot.org/citations/18346205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18346205 | http://www.w3.org/2000/01/rdf-schema#comment | "Aggregation of alpha-synuclein (alpha-SYN) plays a key role in Parkinson's disease. We have previously shown that aggregation of alpha-SYN in vitro is accelerated by addition of FK506 binding proteins (FKBP) and that this effect can be counteracted by FK506, a specific inhibitor of these enzymes. In this paper, we investigated in detail the effect of FKBP12 on early aggregation and on fibril formation of wild-type, A53T and A30P alpha-SYN. FKBP12 has a much smaller effect on the fibril formation of these two clinical mutants alpha-SYN. Using an inactive enzyme, we were able to discriminate between catalytic and non-catalytic effects that differentially influence the two processes. A model explaining non-linear concentration dependencies is proposed."xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2008.05342.x"xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/author | "Engelborghs Y."xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/author | "Gerard M."xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/author | "Brandt I."xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/author | "Debyser Z."xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/author | "Baekelandt V."xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/author | "Baert J."xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/author | "Desender L."xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/pages | "121-133"xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/title | "FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T."xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/18346205 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18346205 |
| http://purl.uniprot.org/citations/18346205 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18346205 |
| http://purl.uniprot.org/uniprot/P62942#attribution-0A9054E18C2C2E69066474786B816ED7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18346205 |
| http://purl.uniprot.org/uniprot/P37840#attribution-69CDBC6983C2C66A3F9648A7762BD3FE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18346205 |
| http://purl.uniprot.org/uniprot/#_A0A087WTS4-mappedCitation-18346205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18346205 |
| http://purl.uniprot.org/uniprot/#_Q0VDC5-mappedCitation-18346205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18346205 |
| http://purl.uniprot.org/uniprot/#_Q0VDC6-mappedCitation-18346205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18346205 |
| http://purl.uniprot.org/uniprot/#_Q1JUQ3-mappedCitation-18346205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18346205 |
| http://purl.uniprot.org/uniprot/#_Q1JUQ5-mappedCitation-18346205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18346205 |
| http://purl.uniprot.org/uniprot/#_Q5W0X3-mappedCitation-18346205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18346205 |