| http://purl.uniprot.org/citations/18347013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18347013 | http://www.w3.org/2000/01/rdf-schema#comment | "The pleiotropic transcription factor nuclear factor-kappaB (NF-kappaB (p50/p65)) regulates the transcription of genes involved in the modulation of cell proliferation, apoptosis, and oncogenesis. Furthermore, a host of solid and hematopoietic tumor types exhibit constitutive activation of NF-kappaB (Basseres, D. S., and Baldwin, A. S. (2006) 25, 6817-6830). However, the mechanism for this constitutive activation of NF-kappaB has not been elucidated in the tumors. We have previously shown that NF-kappaB-inducing kinase (NIK) protein and its association with Inhibitor of kappaB kinase alphabeta are elevated in melanoma cells compared with their normal counterpart, leading to constitutive activation of NF-kappaB. Moreover, expression of dominant negative NIK blocked this base-line NF-kappaB activity in melanoma cells. Of the three receptors that require NIK for activation of NF-kappaB, only the lymphotoxin-beta receptor (LTbeta-R) is expressed in melanoma. We show in this manuscript that for melanoma there is a strong relationship between expression of the LTbeta-R and constitutive NF-kappaB transcriptional activity. Moreover, we show that activation of the LTbeta-R can drive NF-kappaB activity to regulate gene expression that leads to enhanced cell growth. The inhibition by LTbeta-R shRNA resulted in decreased NF-kappaB promoter activity, decreased growth, and decreased invasiveness as compared with control. These results indicate that the LTbeta-R constitutively induces NF-kappaB activation, and this event may be associated with autonomous growth of melanoma cells."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m708272200"xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Su Y."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Ware C.F."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Richmond A."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Kelley M."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Cheung T.C."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Dhawan P."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Ellis D.L."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Sobolik-Delmaire T."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Baugher P."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/author | "Thu Y.M."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/pages | "15399-15408"xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/title | "The lymphotoxin-beta receptor is an upstream activator of NF-kappaB-mediated transcription in melanoma cells."xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18347013 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18347013 |
| http://purl.uniprot.org/citations/18347013 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18347013 |
| http://purl.uniprot.org/uniprot/#_B3KTD9-mappedCitation-18347013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18347013 |
| http://purl.uniprot.org/uniprot/#_P36941-mappedCitation-18347013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18347013 |
| http://purl.uniprot.org/uniprot/#_Q75UT6-mappedCitation-18347013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18347013 |
| http://purl.uniprot.org/uniprot/P36941 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18347013 |