| http://purl.uniprot.org/citations/18350550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18350550 | http://www.w3.org/2000/01/rdf-schema#comment | "Intrathymic deletion of immature thymocytes that express self-reactive TCR specificities is essential in the generation of self tolerance. Medullary thymic epithelial cells (mTEC) expressing the transcriptional regulator Aire play a key role in this process by regulating expression of tissue-restricted antigens to ensure tolerance to peripheral tissues. Here, we have analysed the cellular and molecular requirements for the initial appearance of Aire+ mTEC in the embryonic thymus, in addition to their persistence in the adult thymus. Analysis of thymic ontogeny shows that the emergence of embryonic Aire+ mTEC occurs prior to the appearance of mature thymocytes, and depends upon lymphoid tissue inducer cells expressing retinoic acid receptor-related orphan receptor gamma. In the adult thymus, we show that Aire+ mTEC develop in the absence of thymocyte positive and negative selection and CD40 signalling, but are present at reduced frequency. Collectively these data support a model where the initial differentiation of Aire+ mTEC involves receptor activator of NF-kappaB (RANK)-RANKL interactions with lymphoid tissue inducer cells, with subsequent mTEC turnover and/or survival involving CD40-mediated signalling following interactions with mature CD4+ thymocytes that express CD40L."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200738052"xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/author | "White A.J."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/author | "Scott H.S."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/author | "Anderson G."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/author | "Lane P.J."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/author | "Jenkinson E.J."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/author | "Finke D."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/author | "Parnell S.M."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/author | "Withers D.R."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/pages | "942-947"xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/title | "Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input."xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/18350550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18350550 |
| http://purl.uniprot.org/citations/18350550 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18350550 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ6-mappedCitation-18350550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18350550 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-18350550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18350550 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J096-mappedCitation-18350550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18350550 |
| http://purl.uniprot.org/uniprot/#_A2A5L7-mappedCitation-18350550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18350550 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-18350550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18350550 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-18350550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18350550 |
| http://purl.uniprot.org/uniprot/#_B2MVU6-mappedCitation-18350550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18350550 |