| http://purl.uniprot.org/citations/18353247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18353247 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in either HFE or transferrin receptor 2 (TfR2) cause decreased expression of the iron regulatory hormone hepcidin and hemochromatosis. HFE and TfR2 were recently discovered to form a stable complex at the cell membrane when co-expressed in heterologous cell lines. We analyzed the functional consequences of the co-expression of these proteins using transfected TRVb cells, a Chinese hamster ovary derived cell line without endogenous HFE or transferrin receptor. The co-expression of TfR2 in TRVb cells expressing HFE led to accelerated HFE biosynthesis and late-Golgi maturation, suggesting interaction prior to cell surface localization. The co-expression of HFE in cells expressing TfR2 led to increased affinity for diferric transferrin, increased transferrin-dependent iron uptake, and relative resistance to iron chelation. These observations indicate that HFE influences the functional properties of TfR2, and suggests a model in which the interaction of these proteins might influence signal transduction to hepcidin."xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2008.02.041"xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/author | "Waheed A."xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/author | "Grubb J.H."xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/author | "Sly W.S."xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/author | "Fleming R.E."xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/author | "Britton R.S."xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/name | "Arch Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/pages | "193-197"xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/title | "HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron."xsd:string |
| http://purl.uniprot.org/citations/18353247 | http://purl.uniprot.org/core/volume | "474"xsd:string |
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