| http://purl.uniprot.org/citations/18354179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18354179 | http://www.w3.org/2000/01/rdf-schema#comment | "Ag-specific CD8(+) T cells immunized in the absence of CD4(+) T cell help, so-called "unhelped" CD8(+) T cells, are defective in function and survival. We investigated the role of the proapoptotic molecule TRAIL in this defect. We first demonstrate that TRAIL does not contribute to the CD8(+) T cell response to Listeria monocytogenes strain expressing OVA (LmOVA) in the presence of CD4(+) T cells. Secondly, we generated mice doubly deficient in CD4(+) T cells and TRAIL and analyzed their CD8(+) T cell response to LmOVA. Memory CD8(+) T cells in double-deficient mice waned over time and were not protective against rechallenge, similar to their TRAIL-sufficient unhelped counterparts. To avoid the effects of CD4(+) T cell deficiency during memory maintenance, and to address whether TRAIL plays a role in the early programming of the CD8(+) T cell response, we performed experiments using heterologous prime and early boost immunizations. We did not observe activation-induced cell death of unhelped CD8(+) T cells when mice were infected with followed vaccinia virus expressing OVA 9 days later by LmOVA infection. Furthermore, primary immunization of CD4(+) T cell-deficient mice with cell-associated Ag followed by LmOVA infection did not reveal a role for TRAIL-mediated activation-induced cell death. Overall, our results suggest that CD4(+) T cell help for the CD8(+) T cell response is not contingent on the silencing of TRAIL expression and prevention of TRAIL-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18354179 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.7.4570"xsd:string |
| http://purl.uniprot.org/citations/18354179 | http://purl.uniprot.org/core/author | "Bevan M.J."xsd:string |
| http://purl.uniprot.org/citations/18354179 | http://purl.uniprot.org/core/author | "Sacks J.A."xsd:string |
| http://purl.uniprot.org/citations/18354179 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18354179 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18354179 | http://purl.uniprot.org/core/pages | "4570-4576"xsd:string |
| http://purl.uniprot.org/citations/18354179 | http://purl.uniprot.org/core/title | "TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help."xsd:string |
| http://purl.uniprot.org/citations/18354179 | http://purl.uniprot.org/core/volume | "180"xsd:string |
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