| http://purl.uniprot.org/citations/18356535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18356535 | http://www.w3.org/2000/01/rdf-schema#comment | "Transporters present in the epithelium of the small intestine determine the efficiency by which dietary and biliary cholesterol are taken up into the body and thus control whole-body cholesterol balance. Niemann-Pick C1 Like Protein 1 (Npc1l1) transports cholesterol into the enterocyte, whereas ATP-binding cassette transporters Abca1 and Abcg5/Abcg8 are presumed to be involved in cholesterol efflux from the enterocyte toward plasma HDL and back into the intestinal lumen, respectively. Abca1, Abcg5, and Abcg8 are well-established liver X receptor (LXR) target genes. We examined the effects of a high-fat diet on expression and function of cholesterol transporters in the small intestine in mice. Npc1l1, Abca1, Abcg5, and Abcg8 were all downregulated after 2, 4, and 8 wk on a cholesterol-free, high-fat diet. The high-fat diet did not affect biliary cholesterol secretion but diminished fractional cholesterol absorption from 61 to 42% (P < 0.05). In an acute experiment in which triacylglycerols of unsaturated fatty acids were given by gavage, we found that this downregulation occurs within a 6-h time frame. Studies in LXRalpha-null mice, confirmed by in vitro data, showed that fatty acid-induced downregulation of cholesterol transporters is LXRalpha independent and associated with a posttranslational increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity that reflects induction of cholesterol biosynthesis as well as with a doubling of neutral fecal sterol loss. This study highlights the induction of adaptive changes in small intestinal cholesterol metabolism during exposure to dietary fat."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.00360.2007"xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/author | "Muller M."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/author | "van der Meer R."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/author | "Houten S.M."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/author | "Kuipers F."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/author | "Hooiveld G.J."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/author | "de Wit N.J."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/author | "van der Veen J.N."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/author | "Vermeulen H."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/author | "de Vogel-van den Bosch H.M."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/pages | "G1171-80"xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/title | "A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine."xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/18356535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18356535 |
| http://purl.uniprot.org/citations/18356535 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18356535 |
| http://purl.uniprot.org/uniprot/#_E9QA91-mappedCitation-18356535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18356535 |
| http://purl.uniprot.org/uniprot/#_E9Q0P2-mappedCitation-18356535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18356535 |
| http://purl.uniprot.org/uniprot/#_A3KMG9-mappedCitation-18356535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18356535 |
| http://purl.uniprot.org/uniprot/#_A2RRR0-mappedCitation-18356535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18356535 |
| http://purl.uniprot.org/uniprot/#_A2AGR4-mappedCitation-18356535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18356535 |
| http://purl.uniprot.org/uniprot/#_P41233-mappedCitation-18356535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18356535 |