| http://purl.uniprot.org/citations/18362137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18362137 | http://www.w3.org/2000/01/rdf-schema#comment | "Helicobacter pylori-produced cytotoxin VacA induces intracellular vacuolation. The VacA-induced vacuole is assumed to represent the pathological status of intracellular trafficking. The fusion mechanism of the endosomes requires the formation of a tight complex between the Q-SNAREs and the R-SNAREs. We recently reported that syntaxin 7, a family member of the Q-SNARE protein, is involved in VacA-induced vacuole formation. In order to further elucidate the molecular mechanism, we identified the participation of vesicle-associated membrane protein 7 (VAMP7) as a partner of syntaxin 7. Immunocytochemistry revealed endogenous VAMP7 to be localized to the vacuoles induced by VacA. A Northern blotting study demonstrated that VacA intoxication increased VAMP7 mRNA in a time-dependent manner. VAMP7 was coimmunoprecipitated with syntaxin 7, and the amounts of endogenous VAMP7 and syntaxin 7 bound to syntaxin 7 and VAMP7, respectively, increased in response to VacA. The down-regulation of VAMP7 using small interfering RNA inhibited VacA-induced vacuolation, and the transient transfection of dominant-negative mutant VAMP7, the N-terminal domain of VAMP7, also inhibited the vacuolation. We therefore conclude that R-SNARE VAMP7 plays an important role in VacA-induced vacuolation as a partner of Q-SNARE syntaxin 7."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.01573-07"xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/author | "Hirayama T."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/author | "Ohno H."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/author | "Yasuda H."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/author | "Ohnishi H."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/author | "Suzuki J."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/author | "Omata M."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/author | "Mashima H."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/author | "Yoshikumi Y."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/pages | "2296-2303"xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/title | "Involvement of vesicle-associated membrane protein 7 in human gastric epithelial cell vacuolation induced by Helicobacter pylori-produced VacA."xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/18362137 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18362137 |
| http://purl.uniprot.org/citations/18362137 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18362137 |
| http://purl.uniprot.org/uniprot/#_B4DIH9-mappedCitation-18362137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362137 |
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| http://purl.uniprot.org/uniprot/#_B2R6P4-mappedCitation-18362137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362137 |
| http://purl.uniprot.org/uniprot/#_B4DE96-mappedCitation-18362137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362137 |
| http://purl.uniprot.org/uniprot/#_P51809-mappedCitation-18362137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362137 |
| http://purl.uniprot.org/uniprot/B4DE96 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18362137 |