| http://purl.uniprot.org/citations/18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18362335 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4+ helper T cells contribute to the induction and maintenance of antigen-specific CD8+ T cells. Their absence results in short-lived antigen-specific CD8+ T cells and defective secondary CD8+ T cell responses because of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. Here, we show that IL-15 codelivered with vaccines can overcome CD4+ T cell deficiency for promoting longevity of antigen-specific CD8+ T cells and avoidance of TRAIL-mediated apoptosis. In both priming and secondary responses, IL-15 down-regulates proapoptotic Bax, an intermediate in TRAIL-mediated apoptosis, and increases anti-apoptotic Bcl-X(L) in CD8+ T cells. Thus, IL-15 is sufficient to mimic CD4+ T cell help. Antigen-specific CD4+ T cells induce dendritic cells (DCs) to produce IL-15. IL-15 is also necessary for optimal help, because helper cells do not deliver effective help through IL-15-/-DCs. Therefore, IL-15 codelivered with vaccines can overcome CD4+ helper T cell deficiency for induction of functionally efficient CD8+ T cells and maintenance of CD8+ cytotoxic T lymphocytes (CTLs), and IL-15 is probably one of the natural mediators of help. These findings suggest new vaccine strategies against infections and cancers, especially in individuals with CD4-deficiency."xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0801003105"xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/author | "Ni L."xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/author | "Oh S."xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/author | "Waldmann T.A."xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/author | "Perera L.P."xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/author | "Terabe M."xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/author | "Berzofsky J.A."xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/pages | "5201-5206"xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/title | "IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18362335 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18362335 |
| http://purl.uniprot.org/citations/18362335 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18362335 |
| http://purl.uniprot.org/uniprot/#_A0A0U5CJG6-mappedCitation-18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362335 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ6-mappedCitation-18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362335 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ7-mappedCitation-18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362335 |
| http://purl.uniprot.org/uniprot/#_Q3TZR6-mappedCitation-18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362335 |
| http://purl.uniprot.org/uniprot/#_P50592-mappedCitation-18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362335 |
| http://purl.uniprot.org/uniprot/#_P48346-mappedCitation-18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362335 |
| http://purl.uniprot.org/uniprot/#_Q3U1Z6-mappedCitation-18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362335 |
| http://purl.uniprot.org/uniprot/#_Q3UQ13-mappedCitation-18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362335 |
| http://purl.uniprot.org/uniprot/#_Q3U5H0-mappedCitation-18362335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362335 |