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http://purl.uniprot.org/citations/18362831http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18362831http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Hypoxia-inducible factor 1alpha (HIF-1alpha) is a transcription factor that plays an important role in tumor growth and metastasis. Inhibition of histone deacetylase shows a marked inhibition of HIF-1alpha expression; however, the association between HIF-1alpha and histone deacetylase 1 (HDAC1), metastasis-associated protein 1 (MTA1) is not fully understood.

Methods

Hypoxia-inducible factor 1alpha, HDAC1, and MTA1 expressions were detected by immunohistochemistry in 39 pancreatic carcinoma patients. The correlations between the expression of HIF-1alpha, HDAC1, or MTA1 and clinical features and the prognosis were analyzed.

Results

Hypoxia-inducible factor 1alpha, HDAC1, and MTA1 positive stainings were found in 41%, 56%, and 31%, respectively. There was no correlation between HIF-1alpha, HDAC1, or MTA1 expression levels and any clinical parameters. The survival rate for patients with HIF-1alpha and HDAC1-positive stainings were significantly lower than for patients with HIF-1alpha and HDAC1-negative stainings. The MTA1 overexpression group did not have a significantly lower prognosis than the MTA1 underexpression group. The survival rate for the HDAC1(+)/MTA1(2-3) group was significantly lower than for the other groups.

Conclusions

These results suggest that HIF-1alpha expression may be regulated through HDAC1/MTA1, which is associated with a poor prognosis for pancreatic carcinoma and indicates that HIF-1alpha and HDAC1/MTA1 are a promising therapeutic target in pancreatic carcinoma treatment."xsd:string
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http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/author"Sugimoto K."xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/author"Miyake K."xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/author"Shimada M."xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/author"Yoshizumi T."xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/author"Kanemura H."xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/author"Imura S."xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/author"Batmunkh E."xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/author"Morine Y."xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/name"Pancreas"xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/pages"e1-9"xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/title"Expression of hypoxia-inducible factor-1alpha, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: correlation with poor prognosis with possible regulation."xsd:string
http://purl.uniprot.org/citations/18362831http://purl.uniprot.org/core/volume"36"xsd:string
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