| http://purl.uniprot.org/citations/18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18362887 | http://www.w3.org/2000/01/rdf-schema#comment | "Epstein-Barr virus-encoded small RNA (EBER) is nonpolyadenylated, noncoding RNA, forms stem-loop structure by intermolecular base-pairing giving rise to double-stranded RNA (dsRNA)-like molecule and exists abundantly in EBV-infected cells. EBER induces IL-10 and thus supports the growth of Burkitt's lymphoma (BL) cells. In this study, the mechanism of IL-10 induction by EBER was analysed in the context of dsRNA signaling pathway. Knockdown of retinoic acid-inducible gene I (RIG-I) by small interfering RNA (siRNA), and expression of dominant-negative RIG-I downregulated IL-10 induction in EBER(+) EBV-infected and EBER plasmid-transfected BL cells. Transfection of EBER-expressing plasmid or in vitro synthesized EBER induced IL-10 in RIG-I-expressing cell clones, and activation of IL-10 promoter by EBER was blocked by dominant-negative RIG-I. Blocking of nuclear factor (NF)-kappaB by dominant-negative IkappaB-alpha plasmid did not block IL-10 expression, whereas knockdown of IRF-3 by siRNA resulted in downregulation of IL-10 in EBER(+) BL cells. NF-kappaB is reported to function downstream of RIG-I signaling pathway and is involved in the induction of proinflammatory cytokines. Our results indicate that EBER induces an anti-inflammatory cytokine IL-10 through RIG-I-mediated IRF-3 but not NF-kappaB signaling. These findings suggest a new mechanism of dsRNA signaling pathway that triggers the expression of IL-10, which acts as an autocrine growth factor in BL cells."xsd:string |
| http://purl.uniprot.org/citations/18362887 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2008.75"xsd:string |
| http://purl.uniprot.org/citations/18362887 | http://purl.uniprot.org/core/author | "Iwakiri D."xsd:string |
| http://purl.uniprot.org/citations/18362887 | http://purl.uniprot.org/core/author | "Takada K."xsd:string |
| http://purl.uniprot.org/citations/18362887 | http://purl.uniprot.org/core/author | "Samanta M."xsd:string |
| http://purl.uniprot.org/citations/18362887 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18362887 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/18362887 | http://purl.uniprot.org/core/pages | "4150-4160"xsd:string |
| http://purl.uniprot.org/citations/18362887 | http://purl.uniprot.org/core/title | "Epstein-Barr virus-encoded small RNA induces IL-10 through RIG-I-mediated IRF-3 signaling."xsd:string |
| http://purl.uniprot.org/citations/18362887 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18362887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18362887 |
| http://purl.uniprot.org/citations/18362887 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18362887 |
| http://purl.uniprot.org/uniprot/#_E2GIM5-mappedCitation-18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362887 |
| http://purl.uniprot.org/uniprot/#_E2GIM6-mappedCitation-18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362887 |
| http://purl.uniprot.org/uniprot/#_E2GIM7-mappedCitation-18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362887 |
| http://purl.uniprot.org/uniprot/#_E2GIM8-mappedCitation-18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362887 |
| http://purl.uniprot.org/uniprot/#_E2GIM9-mappedCitation-18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362887 |
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| http://purl.uniprot.org/uniprot/#_Q71UZ1-mappedCitation-18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362887 |
| http://purl.uniprot.org/uniprot/#_Q14653-mappedCitation-18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362887 |
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| http://purl.uniprot.org/uniprot/#_P22301-mappedCitation-18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362887 |
| http://purl.uniprot.org/uniprot/#_Q9BXR7-mappedCitation-18362887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18362887 |