| http://purl.uniprot.org/citations/18363966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18363966 | http://www.w3.org/2000/01/rdf-schema#comment | "Tricho-rhino-phalangeal syndrome (TRPS) is an autosomal dominant skeletal disorder caused by mutations of TRPS1. Based on the similar expression patterns of Trps1 and Gdf5, we hypothesized a possible functional interaction between these two molecules. Using a chondrogenic cell line (ATDC5), we investigated the association of Gdf5-mediated signaling pathways with Trps1 and the phenotypic changes of ATDC5 cells due to over-expression or suppression of Trps1. Treatment of cells with Gdf5 enhanced Trps1 protein levels and phosphorylation of p38 mitogen-activated protein kinase (MAPK) in a dose-dependent manner. Nuclear translocation of Trps1 was also induced by Gdf5. These effects were blocked by a dominant negative form of activin-linked kinase 6 (dn-Alk6) and by SB203580, an inhibitor of the p38 MAPK pathway. Conversely, Gdf5 expression was suppressed by the over-expression of Trps1. Trps1-overexpressing ATDC5 (O/E) cells differentiated into chondrocytes more quickly than mock-infected control cells, whereas cells transfected with dn-Alk6 showed slower differentiation. On the other hand, O/E cells showed an increase of apoptosis along with the up-regulation of cleaved caspase 3 and down-regulation of Bcl-2, whereas dn-Alk6 cells showed suppression of apoptosis. In conclusion, Trps1 acts downstream of the Gdf5 signaling pathway and promotes the differentiation and apoptosis of ATDC5 cells."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2008.01170.x"xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Morimoto Y."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Nishioka K."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Itoh S."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Gai Z."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Muragaki Y."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Kanno S."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Kawakatsu M."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Tanishima H."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Hatamura I."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/author | "Suemoto H."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/pages | "355-363"xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/title | "Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells."xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/18363966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18363966 |
| http://purl.uniprot.org/citations/18363966 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18363966 |
| http://purl.uniprot.org/uniprot/P36898#attribution-9FF088909578D33E9CD1071576AFCB76 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18363966 |
| http://purl.uniprot.org/uniprot/P43027#attribution-9FF088909578D33E9CD1071576AFCB76 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18363966 |
| http://purl.uniprot.org/uniprot/P47811#attribution-9FF088909578D33E9CD1071576AFCB76 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18363966 |
| http://purl.uniprot.org/uniprot/Q925H1#attribution-9FF088909578D33E9CD1071576AFCB76 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18363966 |