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http://purl.uniprot.org/citations/18364377http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18364377http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18364377http://www.w3.org/2000/01/rdf-schema#comment"

Context

Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein.

Objectives

The objective was to investigate the impact of variants in LIPC on metabolic traits and type 2 diabetes in a large sample of Danes. Because behavioral factors influence hepatic lipase activity, we furthermore examined possible gene-environment interactions in the population-based Inter99 study.

Design

The LIPC -250G>A (rs2070895) variant was genotyped in the Inter99 study (n = 6070), the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care Denmark screening cohort of individuals with risk factors for undiagnosed type 2 diabetes (n = 8662), and in additional type 2 diabetic patients (n = 1,064) and glucose-tolerant control subjects (n = 360).

Results

In the Inter99 study, the A allele of rs2070895 associated with a 0.057 mmol/liter [95% confidence interval (CI) 0.039-0.075] increase in fasting serum HDL-cholesterol (HDL-c) (P = 8 x 10(-10)) supported by association in the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care study [0.038 mmol/liter per allele (95% CI 0.024-0.053); P = 2 x 10(-7)). The allelic effect on HDL-c was modulated by interaction with self-reported physical activity (P(interaction) = 0.002) because vigorous physically active homozygous A-allele carriers had a 0.30 mmol/liter (95% CI 0.22-0.37) increase in HDL-c compared with homozygous G-allele carriers.

Conclusions

We validate the association of LIPC promoter variation with fasting serum HDL-c and present data supporting an interaction with physical activity implying an increased effect on HDL-c in vigorous physically active subjects carrying the -250 A allele. This interaction may have potential implications for public health and disease prevention."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.org/dc/terms/identifier"doi:10.1210/jc.2007-2815"xsd:string
http://purl.uniprot.org/citations/18364377http://purl.org/dc/terms/identifier"doi:10.1210/jc.2007-2815"xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Hansen T."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Hansen T."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Jorgensen T."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Jorgensen T."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Pedersen O."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Pedersen O."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Albrechtsen A."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Albrechtsen A."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Andersen M.K."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Andersen M.K."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Grarup N."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Grarup N."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Schmitz O."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Schmitz O."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Borch-Johnsen K."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Borch-Johnsen K."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Lauritzen T."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Lauritzen T."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Sandbaek A."xsd:string
http://purl.uniprot.org/citations/18364377http://purl.uniprot.org/core/author"Sandbaek A."xsd:string
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