| http://purl.uniprot.org/citations/18366072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18366072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18366072 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunoglobulin (Ig) superfamily members are abundant with diverse functions including cell adhesion in various tissues. Here, we identified and characterized a novel adhesion molecule that belongs to the CTX protein family and named as DICAM (Dual Ig domain containing cell adhesion molecule). DICAM is a type I transmembrane protein with two V-type Ig domains in the extracellular region and a short cytoplasmic tail of 442 amino acids. DICAM is found to be expressed ubiquitously in various organs and cell lines. Subcellular localization of DICAM was observed in the cell-cell contact region and nucleus of cultured epithelial cells. Cell-cell contact region was colocalized with tight junction protein, ZO-1. The DICAM increased MDCK cell adhesion to 60% levels of fibronectin. DICAM mediated cell adhesion was specific for the alphavbeta3 integrin; other integrins, alpha2, alpha5, beta1, alpha2beta1, alpha5beta1, were not involved in cell adhesion. In identifying the interacting domain of DICAM with alphavbeta3, the Ig domain 2 showed higher cell adhesion activity than that of Ig domain 1. Although RGD motif in Ig domain 2 was engaged in cell adhesion, it was not participated in DICAM-alphavbeta3 mediated cell adhesion. Furthermore, differentially expressing DICAM stable cells showed well correlated cell to cell adhesion capability with integrin beta3-overexpressing cells. Collectively, these results indicate that DICAM, a novel dual Ig domain containing adhesion molecule, mediates cell adhesion via alphavbeta3 integrin."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.21438"xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.21438"xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Choi J.Y."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Choi J.Y."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Jeong J.H."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Jeong J.H."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Jung Y.K."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Jung Y.K."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Kim H.N."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Kim H.N."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Jin J.S."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Jin J.S."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Park N.R."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/author | "Park N.R."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/name | "J. Cell. Physiol."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/name | "J. Cell. Physiol."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/pages | "603-614"xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/pages | "603-614"xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/title | "DICAM, a novel dual immunoglobulin domain containing cell adhesion molecule interacts with alphavbeta3 integrin."xsd:string |
| http://purl.uniprot.org/citations/18366072 | http://purl.uniprot.org/core/title | "DICAM, a novel dual immunoglobulin domain containing cell adhesion molecule interacts with alphavbeta3 integrin."xsd:string |