| http://purl.uniprot.org/citations/18367534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18367534 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously we have shown that CD8(+) T cells are critical for containment of simian immunodeficiency virus (SIV) viremia and that rapid and profound depletion of CD4(+) T cells occurs in the intestinal tract of acutely infected macaques. To determine the impact of SIV-specific CD8(+) T-cell responses on the magnitude of the CD4(+) T-cell depletion, we investigated the effect of CD8(+) lymphocyte depletion during primary SIV infection on CD4(+) T-cell subsets and function in peripheral blood, lymph nodes, and intestinal tissues. In peripheral blood, CD8(+) lymphocyte-depletion changed the dynamics of CD4(+) T-cell loss, resulting in a more pronounced loss 2 weeks after infection, followed by a temporal rebound approximately 2 months after infection, when absolute numbers of CD4(+) T cells were restored to baseline levels. These CD4(+) T cells showed a markedly skewed phenotype, however, as there were decreased levels of memory cells in CD8(+) lymphocyte-depleted macaques compared to controls. In intestinal tissues and lymph nodes, we observed a significantly higher loss of CCR5(+) CD45RA(-) CD4(+) T cells in CD8(+) lymphocyte-depleted macaques than in controls, suggesting that these SIV-targeted CD4(+) T cells were eliminated more efficiently in CD8(+) lymphocyte-depleted animals. Also, CD8(+) lymphocyte depletion significantly affected the ability to generate SIV Gag-specific CD4(+) T-cell responses and neutralizing antibodies. These results reemphasize that SIV-specific CD8(+) T-cell responses are absolutely critical to initiate at least partial control of SIV infection."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02748-07"xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Lifson J.D."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Williams K."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Brown C.R."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Kim E.Y."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Wolinsky S.M."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Hirsch V.M."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Rieber E.P."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Montefiori D.C."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Schmitz J.E."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Veazey R.S."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Kuroda M.J."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Baumeister S.H."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Foster G.J."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "McEvers K.J."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Newberg M.H."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Rett M.D."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Piatak M. Jr."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/author | "Acierno P.M."xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/pages | "5618-5630"xsd:string |
| http://purl.uniprot.org/citations/18367534 | http://purl.uniprot.org/core/title | "Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys."xsd:string |