| http://purl.uniprot.org/citations/18367646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18367646 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila retinoblastoma family of proteins (RBF1 and RBF2) and their mammalian homologs (pRB, p130, and p107) are best known for their regulation of the G1/S transition via the repression of E2F-dependent transcription. However, RB family members also possess additional functions. Here, we report that rbf1 mutant larvae have extensive defects in chromatin condensation during mitosis. We describe a novel interaction between RBF1 and dCAP-D3, a non-SMC component of the Condensin II complex that links RBF1 to the regulation of chromosome structure. RBF1 physically interacts with dCAP-D3, RBF1 and dCAP-D3 partially colocalize on polytene chromosomes, and RBF1 is required for efficient association of dCAP-D3 with chromatin. dCap-D3 mutants also exhibit chromatin condensation defects, and mutant alleles of dCap-D3 suppress cellular and developmental phenotypes induced by the overexpression of RBF1. Interestingly, this interaction is conserved between flies and humans. The re-expression of pRB into a pRB-deficient human tumor cell line promotes chromatin association of hCAP-D3 in a manner that depends on the LXCXE-binding cleft of pRB. These results uncover an unexpected link between pRB/RBF1 and chromatin condensation, providing a mechanism by which the functional inactivation of RB family members in human tumor cells may contribute to genome instability."xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1631508"xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://purl.uniprot.org/core/author | "Ji J.Y."xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://purl.uniprot.org/core/author | "Dyson N.J."xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://purl.uniprot.org/core/author | "Longworth M.S."xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://purl.uniprot.org/core/author | "Herr A."xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18367646 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://purl.uniprot.org/core/pages | "1011-1024"xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://purl.uniprot.org/core/title | "RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3."xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/18367646 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18367646 |
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| http://purl.uniprot.org/uniprot/#_P58876-mappedCitation-18367646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18367646 |