| http://purl.uniprot.org/citations/18369190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18369190 | http://www.w3.org/2000/01/rdf-schema#comment | "Miranda is a multidomain adaptor protein involved in neuroblast asymmetric division in Drosophila melanogaster. The central domain of Miranda is necessary for cargo binding of the neural transcription factor Prospero, the Prospero-mRNA carrier Staufen, and the tumor suppressor Brat. Here, we report the first solution structure of Miranda central "cargo-binding" domain (residues 460-660) using small-angle X-ray scattering. Ab initio modeling of the scattering data yields an elongated "rod-like" molecule with a maximum linear dimension (D(max)) of approximately 22 nm. Moreover, circular dichroism and cross-linking experiments indicate that the cargo-binding domain is predominantly helical and forms a parallel coiled-coil homodimer in solution. Based on the results, we modeled the full-length Miranda protein as a double-headed, double-tailed homodimer with a long central coiled-coil region. We discuss the cargo-binding capacity of the central domain and propose a structure-based mechanism for cargo release and timely degradation of Miranda in developing neuroblasts."xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.org/dc/terms/identifier | "doi:10.1110/ps.083431408"xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/author | "Kataoka M."xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/author | "Kato R."xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/author | "Kamikubo H."xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/author | "Wakatsuki S."xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/author | "Yousef M.S."xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/name | "Protein Sci"xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/pages | "908-917"xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/title | "Miranda cargo-binding domain forms an elongated coiled-coil homodimer in solution: implications for asymmetric cell division in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/18369190 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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