| http://purl.uniprot.org/citations/18369457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18369457 | http://www.w3.org/2000/01/rdf-schema#comment | "PSORS1 (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate genes were suggested. The most recent study has indicated HLA-Cw6 as the primary PSORS1 risk allele within the candidate region in a Caucasian population. In this study, a family-based association analysis of the PSORS1 locus was performed by analyzing 10 polymorphic microsatellite markers from the PSORS1 region as well as HLA-B, HLA-C and CDSN loci in 163 Chinese families of psoriasis. Five marker loci show strong evidence (P<10(-3)), and one marker locus shows weak evidence (P = 0.04) for association. The haplotype cluster analysis showed that all the risk haplotypes are Cw6 positive and share a 369-kb region of homologous marker alleles which carries all the risk alleles, including HLA-Cw6 and CDSN*TTC, identified in this study. The recombinant haplotype analysis of the HLA-Cw6 and CDSN*TTC alleles in 228 Chinese families showed that the HLA-Cw6(-)/CDSN*TTC(+) recombinant haplotype is clearly not associated with risk for psoriasis (TratioNT = 29:57, p = 0.0025) in a Chinese population, suggesting that the CDSN*TTC allele itself does not confer risk without the presence of the HLA-Cw6 allele. The further exclusion analysis of the non-risk HLA-Cw6(-)/CDSN*TTC(+) recombinant haplotypes with common recombination breakpoints has allowed us to refine the location of PSORS1 to a small candidate region. Finally, we performed a conditional linkage analysis and showed that the HLA-Cw6 is a major risk allele but does not explain the full linkage evidence of the PSORS1 locus in a Chinese population. By performing a series of family-based association analyses of haplotypes as well as an exclusion analysis of recombinant haplotypes, we were able to refine the PSORS1 gene to a small critical region where HLA-C is a strong candidate to be the PSORS1 susceptibility gene."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000038"xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Fan X."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Gao M."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Zhang X.J."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Liu J.J."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Wang Z.M."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Zhang K.Y."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Ren Y.Q."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Liang Y.H."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Sun L.D."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Du W.H."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/author | "Shen Y.J."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/pages | "e1000038"xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/title | "Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population."xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/18369457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18369457 |
| http://purl.uniprot.org/citations/18369457 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18369457 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-18369457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18369457 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-18369457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18369457 |