http://purl.uniprot.org/citations/18371160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/18371160 | http://www.w3.org/2000/01/rdf-schema#comment | "AimAutoimmune hepatitis (AIH) is an organ-specific autoimmune disease characterized by chronic inflammation of the liver. Although the HLA DR4 allele is associated with type 1 AIH in Japanese, the exact genetic etiology of AIH remains undefined. The cytotoxic T-lymphocyte antigen 4 (CTLA4) is an inhibitory receptor expressed by T-cells that acts largely as a negative regulator of T-cell responses, and polymorphisms of CTLA4 have been reported to be associated with susceptibility to various autoimmune diseases. Therefore, we sought to clarify whether CTLA4 single-nucleotide polymorphisms are associated with disease susceptibility in Japanese patients with type 1 AIH.MethodsWe genotyped 76 patients with AIH and 100 ethically matched controls for allelic determinants using TaqMan genotyping assays at four polymorphism sites: -1722 and -318 in the promoter; +49 in exon 1 and +6230 in the 3' untranslated region.ResultsWe observed no difference in the distribution of the alleles, genotypes, or haplotypes between patients and controls. Compared with -1722 C/C patients, -1722 T/T patients were younger (56 vs. 63 years; P = 0.01) and had significantly lower serum levels of aspartate aminotransferase (313 vs. 763 IU/L; P = 0.031) and bilirubin (1.1 vs. 8.6 mg/dL; P = 0.027). Analysis of allelic frequencies revealed no significant difference between patients with and without the HLA DR4 allele.ConclusionThese data suggest that the CTLA4 polymorphism is not associated with susceptibility to type 1 AIH in the Japanese population."xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1872-034x.2008.00337.x"xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/author | "Umemura T."xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/author | "Tanaka E."xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/author | "Katsuyama Y."xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/author | "Ota M."xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/author | "Yoshizawa K."xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/author | "Ichijo T."xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/author | "Kiyosawa K."xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/name | "Hepatol Res"xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/pages | "689-695"xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/title | "Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese."xsd:string |
http://purl.uniprot.org/citations/18371160 | http://purl.uniprot.org/core/volume | "38"xsd:string |
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