| http://purl.uniprot.org/citations/18373953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18373953 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-23-dependent IL-17-producing T helper (Th) lymphocytes are associated with autoimmunity. We investigated the immunopathological mechanisms for activation of Th17 cells of patients with systemic lupus erythematosus (SLE). Concentration of cytokines/chemokine in plasma and culture supernatant from SLE patients and healthy controls were measured by ELISA or flow cytometry. Plasma IL-12, IL-17, IL-23 and CXCL10 concentrations and the number of Th17 cells were significantly elevated in SLE patients than control subjects (both p<0.05). Elevated IL-12, IL-17 and CXCL10 concentrations correlated positively and significantly with SLEDAI (all p<0.05). Plasma IL-12 and IL-17 showed significant and positive correlation with plasma Th1 chemokine CXCL10 concentration in SLE patients (all p<0.05). Ex vivo inductions of IL-17 by IL-23 or IL-18 from co-stimulated lymphocytes were significantly higher in SLE patients than controls (all p<0.05). The activated IL-23/IL-17 axis is important for the inflammatory immunity in SLE."xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.clim.2008.01.019"xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/author | "Wong C.K."xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/author | "Wong P.T."xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/author | "Lam C.W."xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/author | "Li E.K."xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/author | "Tam L.S."xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/author | "Lit L.C."xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/name | "Clin Immunol"xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/pages | "385-393"xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/title | "Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity."xsd:string |
| http://purl.uniprot.org/citations/18373953 | http://purl.uniprot.org/core/volume | "127"xsd:string |
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