| http://purl.uniprot.org/citations/18374904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18374904 | http://www.w3.org/2000/01/rdf-schema#comment | "Conditioned taste aversion (CTA) learning occurs after the pairing of a novel taste with a toxin (e.g. sucrose with LiCl). The immediate early gene c-Fos is necessary for CTA learning, but c-Fos alone cannot be sufficient for consolidation. The expression of other AP-1 proteins from the Fos- and Jun-families may also be required shortly after conditioning for CTA consolidation. To screen for the expression of AP-1 transcription factors within small subregions, RT-PCR analysis was used after laser capture microdissection of the amygdala. Rats were infused intraorally with 5% sucrose (6 ml/6 min) or injected with LiCl (12 ml/kg, 0.15 M, i.p.) or given sucrose paired with LiCl (sucrose/LiCl), or not treated; 1 h later their brains were dissected. The lateral (LA), basolateral (BLA), and central (CeA) subnuclei of the amgydala of single 5 microm sections from individual rats were dissected using the Arcturus PixCell II system. Semi-quantitative RT-PCR showed the consistent presence of c-Fos, Fra-2, c-Jun, and JunD in the amygdala. In situ hybridization confirmed that c-Fos and Fra-2 mRNA expression was increased in the CeA after LiCl and sucrose/LiCl treatment. Immunohistochemistry for Fra-2 revealed high baseline levels of Fra-2 protein in the BLA and CeA, but also an increase in Fra-2 in the BLA and CeA after LiCl and sucrose/LiCl treatment. The similarity of response in LiCl and sucrose/LiCl treated groups might reflect activation by LiCl in both groups. To control for the effects of LiCl, rats were tested in a learned safety experiment. Fra-2 and c-Fos were examined in response to sucrose/LiCl in rats with prior familiarity with sucrose compared to rats without prior exposure to sucrose. The familiar (pre-exposure) group showed a significantly decreased number of Fra-2-positive cells compared with the novel group in the BLA, but not in the CeA. Because pre-exposure to sucrose attenuates CTA learning, a decreased cellular response in pre-exposed rats suggests a specific correlation with CTA learning. Changes in Fra-2 and c-Fos expression in the BLA and CeA at the time of conditioning, together with constitutive expression of c-Jun and JunD, may contribute to CTA learning."xsd:string |
| http://purl.uniprot.org/citations/18374904 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2008.01.072"xsd:string |
| http://purl.uniprot.org/citations/18374904 | http://purl.uniprot.org/core/author | "Goltz M."xsd:string |
| http://purl.uniprot.org/citations/18374904 | http://purl.uniprot.org/core/author | "Kwon B."xsd:string |
| http://purl.uniprot.org/citations/18374904 | http://purl.uniprot.org/core/author | "Houpt T.A."xsd:string |
| http://purl.uniprot.org/citations/18374904 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18374904 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/18374904 | http://purl.uniprot.org/core/pages | "128-141"xsd:string |
| http://purl.uniprot.org/citations/18374904 | http://purl.uniprot.org/core/title | "Expression of AP-1 family transcription factors in the amygdala during conditioned taste aversion learning: role for Fra-2."xsd:string |
| http://purl.uniprot.org/citations/18374904 | http://purl.uniprot.org/core/volume | "1207"xsd:string |
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