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http://purl.uniprot.org/citations/18376313http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18376313http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Interleukin (IL) 22 is a recently identified T-cell-derived cytokine. IL-22 binds at the cell surface to a heterodimer receptor complex composed of IL-22 receptor (R) 1 and IL-10R2. In this study, we performed immunohistochemical analyses for IL-22R1 expression in human pancreatic tissue.

Methods

Normal human pancreatic tissue (n = 8) was immunostained with antihuman IL-22R1 antibodies following standard immunohistochemical procedures.

Results

In the normal human pancreas, IL-22R1 was expressed in the islets of Langerhans. IL-22R1 was not expressed by the acinar cells and ductal epithelium. Double-immunostaining experiments showed that the majority of insulin-expressing beta cells and glucagon-expressing alpha cells were immunopositive for IL-22R1.

Conclusions

The islets of Langerhans are the local site for IL-22R1 expression in the human pancreas. It may be that the T-cell-mediated immune response modulates cell islet function through IL-22 signaling."xsd:string
http://purl.uniprot.org/citations/18376313http://purl.org/dc/terms/identifier"doi:10.1097/mpa.0b013e3181594258"xsd:string
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/author"Nishida A."xsd:string
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/author"Andoh A."xsd:string
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/author"Fujiyama Y."xsd:string
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/author"Shioya M."xsd:string
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/author"Kakinoki S."xsd:string
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/name"Pancreas"xsd:string
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/pages"197-199"xsd:string
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/title"Interleukin 22 receptor 1 expression in pancreas islets."xsd:string
http://purl.uniprot.org/citations/18376313http://purl.uniprot.org/core/volume"36"xsd:string
http://purl.uniprot.org/citations/18376313http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18376313
http://purl.uniprot.org/citations/18376313http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18376313
http://purl.uniprot.org/uniprot/#_B4E2V9-mappedCitation-18376313http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18376313
http://purl.uniprot.org/uniprot/#_Q8N6P7-mappedCitation-18376313http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18376313
http://purl.uniprot.org/uniprot/B4E2V9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18376313
http://purl.uniprot.org/uniprot/Q8N6P7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18376313