| http://purl.uniprot.org/citations/18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18378044 | http://www.w3.org/2000/01/rdf-schema#comment | "The aging program mediated by IGF1-R is responsible for a naturally occurring TrkA to p75(NTR) switch that leads to activation of the second messenger ceramide and increased production of the Alzheimer's disease amyloid beta-peptide. Biochemical and genetic approaches that target IGF1-R signaling, p75(NTR), or ceramide are able to block the above events. Here, we show that the transcription factors Egr-1 and Hipk2 are required elements for the TrkA to p75(NTR) switch downstream of IGF1-R signaling. Specifically, Egr-1 is required for the upregulation of p75(NTR), whereas Hipk2 is required for the downregulation of TrkA. In fact, gene silencing of Egr-1 abolished the ability of IGF1 to upregulate p75(NTR), whereas similar approaches directed against Hipk2 blocked the downregulation of TrkA. In addition, IGF1 treatment favored binding of Egr-1 and Hipk2 to the promoter of p75(NTR) and TrkA, respectively. Finally, the expression levels of both Egr-1 and Hipk2 are upregulated in an age-dependent fashion. Such an event is opposed by caloric restriction, a model of delayed aging, and favored by the p44 transgene in p44(+/+) animals, a model of accelerated aging."xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2008.02.015"xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/author | "Puglielli L."xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/author | "Scrable H."xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/author | "Costantini C."xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/author | "Weindruch R."xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/pages | "2010-2020"xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/title | "Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R."xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/18378044 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18378044 |
| http://purl.uniprot.org/citations/18378044 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18378044 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J202-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J204-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |
| http://purl.uniprot.org/uniprot/#_E9QNX9-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |
| http://purl.uniprot.org/uniprot/#_P02340-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |
| http://purl.uniprot.org/uniprot/#_P08046-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |
| http://purl.uniprot.org/uniprot/#_Q3UVJ3-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |
| http://purl.uniprot.org/uniprot/#_Q3UZU7-mappedCitation-18378044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18378044 |