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http://purl.uniprot.org/citations/18379127http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18379127http://www.w3.org/2000/01/rdf-schema#comment"

Objective

the aim of present study is to determine possible contributions of INF-gamma inducible chemochine CXCL-10 in the thyroid color doppler ultrasound (CDU) parameters typical of autoimmune disorders.

Methods

we studied a consecutive series of 25 patients with autoimmune thyroid disease and 10 healthy control subjects. All subjects underwent a thyroid CDU examination by the same investigator, who was unaware of the laboratory values at the time of the examination. Moreover, all subjects underwent a clinical evaluation, CXCL-10 and thyroid hormonal assessment.

Results

CXCL-10 levels were significantly higher in patients with autoimmune diseases and as well as in subjects with an increased thyroid vascularization at CDU. Moreover, CXCL-10 levels were significantly (p<0.05) correlated with inferior thyroid arteria peak systolic velocity (ITA-PSV; r = 0.376) and with thyroid volume even after adjustment for confounding factors. No difference was observed between vascular thyroid pattern at CDU and thyroid circulating hormones while, ITA-PSV was significantly associated with TSH (Adj. r = -0.373; p<0.05).

Conclusions

our data seem to suggest that CXCL-10 could play an important role in the intra-thyroid angiogenesis modulation, explaining, at least partiality, CDU findings typical of thyroid autoimmune diseases. Moreover we confirmed previous reports considering ITA-PSV as the best CDU parameters in the differential diagnosis of thyroid autoimmune disorders."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.org/dc/terms/identifier"doi:10.1507/endocrj.k07e-052"xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/author"Rotondi M."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/author"Serio M."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/author"Corona G."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/author"Biagini C."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/author"Petrone L."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/author"Conforti B."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/author"Forti G."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/author"Bonamano A."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/author"Cremonini N."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/name"Endocr J"xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/pages"345-350"xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/title"Correlation between, clinical, biochemical, color Doppler ultrasound thyroid parameters, and CXCL-10 in autoimmune thyroid diseases."xsd:string
http://purl.uniprot.org/citations/18379127http://purl.uniprot.org/core/volume"55"xsd:string
http://purl.uniprot.org/citations/18379127http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18379127
http://purl.uniprot.org/citations/18379127http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18379127
http://purl.uniprot.org/uniprot/#_P02778-mappedCitation-18379127http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18379127
http://purl.uniprot.org/uniprot/P02778http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18379127