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http://purl.uniprot.org/citations/18381799http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18381799http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To analyze whether the polymorphisms -22 (G/C) and -348 (C/T) of the BAT1 gene are associated with susceptibility to rheumatoid arthritis (RA).

Methods

One hundred fifty-six patients with RA and 154 controls were genotyped for HLA-DRB1 and the polymorphisms -22 and -348 of the BAT1 gene.

Results

HLA-DRB1*04 alleles were associated with RA susceptibility (33.9% vs 20.1%; pc = 0.04). Among these, HLA-DRB1*0401 (13.4% vs 5.1%; pc = 0.04) and HLA-DRB1*0404 (5.7% vs 1.2%; pc = 0.2) were increased in patients with RA. Additionally, carriage of BAT1 -348T polymorphism was strongly associated with RA (23.7% vs 12.1%; pc = 0.0002). Significantly, BAT1 -348T was in linkage disequilibrium with HLA-DRB1*0404 and HLA-DRB1*0405. However, BAT1 -348 T was associated independently with HLA-DRB1 shared-epitope alleles (42.6% vs 18.9%; p = 0.001).

Conclusion

The BAT1 -348T polymorphism is associated with RA susceptibility independently of HLA-DRB1. The role of BAT1 in the regulation of tumor necrosis factor-a suggests that BAT1 may regulate the inflammatory response observed in patients with RA."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/author"Gonzalez S."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/author"Lopez-Larrea C."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/author"Alperi-Lopez M."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/author"Ballina-Garcia F.J."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/author"Lopez-Soto A."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/author"Lopez-Vazquez A."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/author"Queiro-Silva R."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/author"Quinones-Lombrana A."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/name"J Rheumatol"xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/pages"741-744"xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/title"BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility."xsd:string
http://purl.uniprot.org/citations/18381799http://purl.uniprot.org/core/volume"35"xsd:string
http://purl.uniprot.org/citations/18381799http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18381799
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