| http://purl.uniprot.org/citations/18382127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18382127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18382127 | http://www.w3.org/2000/01/rdf-schema#comment | "CARP1 and CARP2 proteins (CARPs) are E3 ligases that target p53 as well as phospho-p53 for degradation. Because MDM2 is a critical regulator of p53 turnover, we investigated and found that CARPs associate with MDM2. We provide evidence that CARPs stabilize MDM2 by inhibiting MDM2 self-ubiquitination. CARPs together with MDM2 enhance p53 degradation, thereby inhibiting p53-mediated cell death. CARP protein levels correlate with MDM2 levels including under hypoxia where both are reduced. CARP2 was found to target 14-3-3sigma for degradation, leading to MDM2 stabilization. MDMX, a homolog of MDM2, is not absolutely required for MDM2 stabilization by CARPs, although overexpression of CARP2 enhances MDM2/MDMX interaction. Taken together, our study identifies novel mechanisms by which CARP proteins regulate the p53 signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.7.5.5701"xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.7.5.5701"xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/author | "Dicker D.T."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/author | "Dicker D.T."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/author | "El-Deiry W.S."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/author | "El-Deiry W.S."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/pages | "670-682"xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/pages | "670-682"xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/title | "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/title | "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2."xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/18382127 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18382127 |
| http://purl.uniprot.org/citations/18382127 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18382127 |