| http://purl.uniprot.org/citations/18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18384122 | http://www.w3.org/2000/01/rdf-schema#comment | "Astrocyte activation is involved in the neuropathic pain. As a glutamate scavenger, the glutamate transporter-1 (GLT-1) is exclusively expressed on the astrocytes and probably correlates with astrocyte activation. In the present study, we attempted to clarify the temporal changing courses of astrocyte activation and GLT-1 expression, as well as their correlations induced by a neuropathic pain model, namely, spinal nerve ligation (SNL) in which rapidly appearing (<3 days) and persistent (>21 days) mechanical allodynia and thermal hyperalgesia were presented. Immunofluorescent staining showed that GLT-1 was expressed exclusively in most (not all) of the astrocytes, even when the GLT-1 expression reached its peak. The expression of GLT-1 displayed an interesting biphasic change, with an initial up-regulation followed by a down-regulation after SNL. Our results also demonstrated that SNL induced a marked and long-term (>21 days) activation of astrocytes in the ipsilateral spinal dorsal horn. These results suggest that astrocyte activation, the change of GLT-1 expression and the potential relationship between them might play key roles in the induction and/or maintenance of neuropathic pain. The present results provide novel clues in understanding the mechanisms underlying the involvement of astrocytes and GLT-1 in the neuropathic pain."xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.org/dc/terms/identifier | "doi:10.1002/ar.20673"xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/author | "Li Y.Q."xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/author | "Wang W.'"xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/name | "Anat Rec (Hoboken)"xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/pages | "513-518"xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/title | "Temporal changes of astrocyte activation and glutamate transporter-1 expression in the spinal cord after spinal nerve ligation-induced neuropathic pain."xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/18384122 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18384122 |
| http://purl.uniprot.org/citations/18384122 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18384122 |
| http://purl.uniprot.org/uniprot/#_A0A159KIH4-mappedCitation-18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18384122 |
| http://purl.uniprot.org/uniprot/#_A0A159KIL2-mappedCitation-18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18384122 |
| http://purl.uniprot.org/uniprot/#_A6HNP2-mappedCitation-18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18384122 |
| http://purl.uniprot.org/uniprot/#_A6HNP3-mappedCitation-18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18384122 |
| http://purl.uniprot.org/uniprot/#_A6HNP4-mappedCitation-18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18384122 |
| http://purl.uniprot.org/uniprot/#_A6HNP5-mappedCitation-18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18384122 |
| http://purl.uniprot.org/uniprot/#_I1T7F1-mappedCitation-18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18384122 |
| http://purl.uniprot.org/uniprot/#_Q6PUA8-mappedCitation-18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18384122 |
| http://purl.uniprot.org/uniprot/#_P31596-mappedCitation-18384122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18384122 |