| http://purl.uniprot.org/citations/18385325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18385325 | http://www.w3.org/2000/01/rdf-schema#comment | "A systematic forward genetic Drosophila screen for electroretinogram mutants lacking synaptic transients identified the fuseless (fusl) gene, which encodes a predicted eight-pass transmembrane protein in the presynaptic membrane. Null fusl mutants display >75% reduction in evoked synaptic transmission but, conversely, an approximately threefold increase in the frequency and amplitude of spontaneous synaptic vesicle fusion events. These neurotransmission defects are rescued by a wild-type fusl transgene targeted only to the presynaptic cell, demonstrating a strictly presynaptic requirement for Fusl function. Defects in FM dye turnover at the synapse show a severely impaired exo-endo synaptic vesicle cycling pool. Consistently, ultrastructural analyses reveal accumulated vesicles arrested in clustered and docked pools at presynaptic active zones. In the absence of Fusl, calcium-dependent neurotransmitter release is dramatically compromised and there is little enhancement of synaptic efficacy with elevated external Ca(2+) concentrations. These defects are causally linked with severe loss of the Cacophony voltage-gated Ca(2+) channels, which fail to localize normally at presynaptic active zone domains in the absence of Fusl. These data indicate that Fusl regulates assembly of the presynaptic active zone Ca(2+) channel domains required for efficient coupling of the Ca(2+) influx and synaptic vesicle exocytosis during neurotransmission."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5553-07.2008"xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/author | "Woodruff E."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/author | "An L."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/author | "Pak W.L."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/author | "Doerge R.W."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/author | "Broadie K."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/author | "Leung H.T."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/author | "Long A.A."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/pages | "3668-3682"xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/title | "Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein."xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18385325 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18385325 |
| http://purl.uniprot.org/citations/18385325 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18385325 |
| http://purl.uniprot.org/uniprot/Q7K3S3#attribution-20F356698ED8C60EFBB2E94ACB473F10 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18385325 |
| http://purl.uniprot.org/uniprot/Q7K3S3#attribution-E2E2B773063A4DE91BA936428CDD1996 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18385325 |
| http://purl.uniprot.org/uniprot/#_A0A4D6K1U1-mappedCitation-18385325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18385325 |
| http://purl.uniprot.org/uniprot/#_A0A4D6K2Y1-mappedCitation-18385325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18385325 |
| http://purl.uniprot.org/uniprot/#_A0A4D6K2Y3-mappedCitation-18385325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18385325 |
| http://purl.uniprot.org/uniprot/#_M9NF25-mappedCitation-18385325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18385325 |
| http://purl.uniprot.org/uniprot/#_O18660-mappedCitation-18385325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18385325 |