| http://purl.uniprot.org/citations/18387310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18387310 | http://www.w3.org/2000/01/rdf-schema#comment | "T cells and T cell derived cytokines are involved in the complex pathogenesis of asthma. The role of the cytokine IL-18 however, is not clearly defined so far. On the one hand side IL-18 induces Th1-type cytokines and thereby might counter-regulate Th2-mediated allergic asthma. On the other hand IL-18 also bears pro-inflammatory effects possibly enhancing experimental asthma. In order to elucidate the role of IL-18 in allergic pulmonary inflammation typical symptoms were compared after induction of experimental asthma in IL-18(-/-) and in wild type mice. Asthma was induced using ovalbumin (OVA) as allergen for sensitization and challenge. Sham sensitized and OVA challenged mice served as controls. Bronchoalveolar lavage-fluid cytology, leukocyte infiltration in lung tissues, serum levels of OVA-specific IgE and cytokines, and lung function were analyzed. Clear differences could be observed between control and asthmatic mice, both in wild type and IL-18(-/-) animals. Surprisingly, no differences were found between asthmatic wild type and IL-18(-/-) mice. Thus, in contrast to conflicting data in the literature IL-18 did not suppress or enhance the pulmonary allergic immune response in a murine experimental model of asthma."xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2008.02.012"xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/author | "Braun A."xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/author | "Neumann D."xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/author | "Tschernig T."xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/author | "Hartwig C."xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/author | "Mazzega M."xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/pages | "298-305"xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/title | "Endogenous IL-18 in experimentally induced asthma affects cytokine serum levels but is irrelevant for clinical symptoms."xsd:string |
| http://purl.uniprot.org/citations/18387310 | http://purl.uniprot.org/core/volume | "42"xsd:string |
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