| http://purl.uniprot.org/citations/18388318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18388318 | http://www.w3.org/2000/01/rdf-schema#comment | "Myoblast fusion takes place in two steps in mammals and in Drosophila. First, founder cells (FCs) and fusion-competent myoblasts (FCMs) fuse to form a trinucleated precursor, which then recruits further FCMs. This process depends on the formation of the fusion-restricted myogenic-adhesive structure (FuRMAS), which contains filamentous actin (F-actin) plugs at the sites of cell contact. Fusion relies on the HEM2 (NAP1) homolog Kette, as well as Blow and WASP, a member of the Wiskott-Aldrich-syndrome protein family. Here, we show the identification and characterization of schwächling--a new Arp3-null allele. Ultrastructural analyses demonstrate that Arp3 schwächling mutants can form a fusion pore, but fail to integrate the fusing FCM. Double-mutant experiments revealed that fusion is blocked completely in Arp3 and wasp double mutants, suggesting the involvement of a further F-actin regulator. Indeed, double-mutant analyses with scar/WAVE and with the WASP-interacting partner vrp1 (sltr, wip)/WIP show that the F-actin regulator scar also controls F-actin formation during myoblast fusion. Furthermore, the synergistic phenotype observed in Arp3 wasp and in scar vrp1 double mutants suggests that WASP and SCAR have distinct roles in controlling F-actin formation. From these findings we derived a new model for actin regulation during myoblast fusion."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.022269"xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Schafer G."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Palmer R.H."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Berger S."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Holz A."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Eriksson T."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Klambt C."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Renkawitz-Pohl R."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Beck L."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Kesper D.A."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/author | "Onel S.F."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/pages | "1303-1313"xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/title | "WASP and SCAR have distinct roles in activating the Arp2/3 complex during myoblast fusion."xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/18388318 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18388318 |
| http://purl.uniprot.org/citations/18388318 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18388318 |
| http://purl.uniprot.org/uniprot/P32392#attribution-37C0604AF59F07BA7EE41FC0F24066D6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18388318 |
| http://purl.uniprot.org/uniprot/E1JGR7#attribution-37C0604AF59F07BA7EE41FC0F24066D6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18388318 |
| http://purl.uniprot.org/uniprot/E1JGR7#attribution-E966395ECF620E547ADD1DD4D893559A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18388318 |
| http://purl.uniprot.org/uniprot/Q8SX98#attribution-37C0604AF59F07BA7EE41FC0F24066D6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18388318 |
| http://purl.uniprot.org/uniprot/Q8SX98#attribution-E966395ECF620E547ADD1DD4D893559A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18388318 |