| http://purl.uniprot.org/citations/18388859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18388859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18388859 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously identified a protein, consisting of seven WD-repeats, forming a putative beta-propeller, and an FYVE domain, ProF, which is highly expressed in 3T3-L1 cells, a cell line that can be differentiated into adipocytes. We recently found ProF to interact with the kinases Akt and protein kinase Czeta. Here we demonstrate that ProF is a positive regulator of adipogenesis. Knockdown of ProF by RNA interference leads to decreased adipocyte differentiation. This is shown by reduced lipid accumulation, decreased expression of the differentiation markers PPARgamma and C/EBPalpha, and reduced glucose uptake in differentiated cells. Furthermore, ProF overexpression leads to increased adipogenesis. ProF binds to the transcription factor Foxo1 (Forkhead box O1), a negative regulator of insulin action and adipogenesis, and facilitates the phosphorylation and thus inactivation of Foxo1 by Akt. Additionally, dominant-negative Foxo1 restores adipogenesis in ProF knockdown cells. Thus, ProF modulates Foxo1 phosphorylation by Akt, promoting adipocyte differentiation. Furthermore, ProF might be involved in metabolic disorders such as diabetes."xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.67"xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.67"xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/author | "Moelling K."xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/author | "Moelling K."xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/author | "Fritzius T."xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/author | "Fritzius T."xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/pages | "1399-1410"xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/pages | "1399-1410"xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/title | "Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/title | "Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18388859 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18388859 |
| http://purl.uniprot.org/citations/18388859 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18388859 |
| http://purl.uniprot.org/citations/18388859 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18388859 |
| http://purl.uniprot.org/citations/18388859 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18388859 |
| http://purl.uniprot.org/uniprot/Q96P53 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18388859 |
| http://purl.uniprot.org/uniprot/Q8BUB4 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18388859 |