| http://purl.uniprot.org/citations/18389477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18389477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18389477 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-10 is a potent anti-inflammatory cytokine interfering with antigen presentation by inducing the intracellular sequestration of MHC class II (MHC-II) molecules. Here we studied the contribution of membrane-associated RING-CH (MARCH) ubiquitin ligase family members to the IL-10-induced down-regulation of MHC-II molecules. We found that MARCH1 and MARCH8 proteins are the most potent family members for the down-regulation of MHC-II surface expression in transfected cells, but only MARCH1 mRNA expression is strongly induced by IL-10 in human primary monocytes. We detected mono- and poly-ubiquitinated forms of MHC-II molecules both in IL-10-treated monocytes and in cells transfected with MARCH1. We also show direct interaction between MHC-II and MARCH1 molecules in co-immunoprecipitation assays. Finally, we found that siRNA-mediated knockdown of MARCH1 reverses IL-10-induced MHC-II down-regulation in primary monocytes. Thus, the immunosuppressive effect of IL-10 on antigen presentation is mediated through induced expression of MARCH1."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200737902"xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200737902"xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Brunet A."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Brunet A."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Cloutier M."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Cloutier M."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Bartee E."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Bartee E."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Fruh K."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Fruh K."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Houde M."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Houde M."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Tremblay J."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Tremblay J."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Lamarre D."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Lamarre D."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Bontron S."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Bontron S."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Gatti E."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Gatti E."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Steimle V."xsd:string |
| http://purl.uniprot.org/citations/18389477 | http://purl.uniprot.org/core/author | "Steimle V."xsd:string |