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http://purl.uniprot.org/citations/18390988http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18390988http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Polyglandular failure or autoimmunity (PGA) involves at least two endocrine diseases. Several genes may play a role in its etiology. This study analyzed 1) whether HLA-DRB1, HLA-DQB1, and MHC class I chain-related gene A (MICA) polymorphisms are associated in PGA and 2) whether PGA patients display stronger associations with these immune genes than patients with monoglandular autoimmunity (MGA).

Design

Association study.

Methods

HLA-DRB1, HLA-DQB1, and MICA alleles were analyzed in 73 patients with PGA, 283 with MGA, and 206 healthy controls. The HLA-DRB1 and HLA-DQB1 polymorphisms were determined with PCR-amplified DNA being hybridized with PCR-sequence-specific oligonucleotide probes. MICA microsatellites were typed by PCR amplification and fragment size analysis on a DNA sequencer.

Results

HLA-DRB1*03 was strongly increased in patients with PGA (50.7%) versus both controls (21.8%, P(c)<0.0001; RR=2.32, 95% CI=1.62-3.33) and MGA (11.4%, P(c)<0.0001). HLA-DRB1*03 was highly prevalent in PGA patients with early versus late disease onset (P<0.05, logistic regression analysis). HLA-DRB1*04 allele carriers were more present in PGA versus controls (53.4% vs 22.4%, P(c)<0.0001, RR=2.38, 95% CI=1.68-3.38). Further, HLA-DQB1*02 was increased in PGA versus controls (P(c)<0.01), whereas HLA-DQB1*06 was decreased (P(c)<0.001). Patients with PGA showed more MIC A5.1 and less MIC A6 allele carriers than controls (NS). Presence of the MIC A5.1 allele was not associated with the HLA-DRB1*03 or HLA-DQB1 alleles.

Conclusions

HLA-DRB1*03 is a stronger genetic marker in PGA than in MGA, foremost in those with early disease onset."xsd:string
http://purl.uniprot.org/citations/18390988http://purl.org/dc/terms/identifier"doi:10.1530/eje-08-0082"xsd:string
http://purl.uniprot.org/citations/18390988http://purl.uniprot.org/core/author"Ide M."xsd:string
http://purl.uniprot.org/citations/18390988http://purl.uniprot.org/core/author"Wurm M."xsd:string
http://purl.uniprot.org/citations/18390988http://purl.uniprot.org/core/author"Dittmar M."xsd:string
http://purl.uniprot.org/citations/18390988http://purl.uniprot.org/core/author"Kahaly G.J."xsd:string
http://purl.uniprot.org/citations/18390988http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18390988http://purl.uniprot.org/core/name"Eur J Endocrinol"xsd:string
http://purl.uniprot.org/citations/18390988http://purl.uniprot.org/core/pages"55-60"xsd:string
http://purl.uniprot.org/citations/18390988http://purl.uniprot.org/core/title"Early onset of polyglandular failure is associated with HLA-DRB1*03."xsd:string
http://purl.uniprot.org/citations/18390988http://purl.uniprot.org/core/volume"159"xsd:string
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