| http://purl.uniprot.org/citations/18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18391981 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycogen synthase kinase-3 (GSK-3beta) regulates microtubule dynamics and cellular polarity through phosphorylating various microtubule associating proteins and plus-end tracking proteins. Although it was also reported that GSK-3beta is inactivated by protein kinase B at the spindle poles, functions and targets of GSK-3beta in the mitotic phase are unknown. Here, we identified Aurora-A-interacting protein (AIP), a negative regulator of Aurora-A, as a binding partner of GSK-3beta. AIP was colocalized with Aurora-A and GSK-3beta to the spindle poles in metaphase, and its depletion in cells stabilized and activated Aurora-A in early mitotic phase and caused mitotic cell arrest. Treatment of the cells with a GSK-3beta inhibitor reduced the protein level of Aurora-A and this reduction was suppressed by AIP knockdown. AIP was phosphorylated by GSK-3beta, and an AIP mutant in which the GSK-3beta phosphorylation site was mutated could bind and downregulate Aurora-A more efficiently. These results suggest that GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP."xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2008.92"xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://purl.uniprot.org/core/author | "Lee P.C."xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://purl.uniprot.org/core/author | "Saya H."xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://purl.uniprot.org/core/author | "Fumoto K."xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18391981 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://purl.uniprot.org/core/pages | "4478-4487"xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://purl.uniprot.org/core/title | "AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta."xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18391981 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18391981 |
| http://purl.uniprot.org/citations/18391981 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18391981 |
| http://purl.uniprot.org/uniprot/#_A0A3B3ITW1-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/#_B2R6Z3-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/#_B4DX16-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/#_B5BUC0-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/#_P49841-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/#_Q86TM2-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/#_O14965-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/#_Q6FI27-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/#_Q6PI41-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/#_Q9NWT8-mappedCitation-18391981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18391981 |
| http://purl.uniprot.org/uniprot/P49841 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18391981 |