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http://purl.uniprot.org/citations/18393128http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18393128http://www.w3.org/2000/01/rdf-schema#comment"

Objective

In recent years, thyroid cancer has been at the forefront of molecular pathology as a result of the consequences of the Chernobyl disaster and the recognition of the role of RET/PTC rearrangements in papillary thyroid carcinomas (PTCs). Correlation of RET/PTC expression with clinical outcome is controversial. This study aims to identify the prevalence of RET/PTC oncogene expression in Turkey, and to investigate the correlation between RET/PTC oncogene expression and the known prognostic factors of PTC in 101 patients.

Methods

The RET rearrangements were examined by means of reverse transcriptase-polymerase chain reaction analysis, with primers flanking the chimeric region. Statistical evaluation was performed by using Independent samples t-test, One-sample Chi-square test and Pearson Chi-square or Fisher's Exact Test.

Results

RET/PTC was determined positive in 67(66.3%) of totally 101 patients (p<0.001). RET/PTC1 in 32(31.7%), RET/PTC3 in 21(20.8%), RET/PTC1+RET/PTC3 both in 10(9.9%) patients were found to be positive. There was RET/PTC2 positiveness in two patients, RET/PTC2,3 positiveness in one patient, and RET/PTC1,2,3 positiveness in one patient. No statistical difference was found between RET/PTC1 and RET/PTC3. None of genetico-clinical analyses showed any significant association between RET/PTC expression and the clinical and pathological features of the cancers.

Conclusion

While this prevalence of the RET/PTC is less than RET/PTC frequency seen after Chernobyl in Belarus, its prevalence in our region is also high (66.3%). As a result, no significant correlation was found in between prognosis and RET/PTC frequency."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.org/dc/terms/identifier"doi:10.1055/s-2007-992153"xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Berdeli A."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Yilmaz C."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Erdogan M."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Saygili F."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Tuncyurek M."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Karadeniz M."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Ozgen A.G."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Ertan Y."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Kabalak T."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Tuzun M."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Uluer H."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/author"Cetinkalp S."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/name"Exp Clin Endocrinol Diabetes"xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/pages"225-230"xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/title"The prevalence of RET/PTC mutations in papillary thyroid cancers in Turkish population and its relation between tumor histopathology and prognostic factors."xsd:string
http://purl.uniprot.org/citations/18393128http://purl.uniprot.org/core/volume"116"xsd:string
http://purl.uniprot.org/citations/18393128http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18393128
http://purl.uniprot.org/citations/18393128http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18393128
http://purl.uniprot.org/uniprot/#_F5CNE9-mappedCitation-18393128http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18393128
http://purl.uniprot.org/uniprot/#_B4DGX8-mappedCitation-18393128http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18393128
http://purl.uniprot.org/uniprot/#_F8TLS5-mappedCitation-18393128http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18393128
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