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http://purl.uniprot.org/citations/18395252http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18395252http://www.w3.org/2000/01/rdf-schema#comment"The current study attempts to characterize the eosinophilia associated with T-cell lymphomas and to investigate its possible relationship with the secretion of eosinophil-stimulating factors by lymphoma cells and/or intra-tumoral surrounding cells. Paraffin-embedded specimens from 50 patients diagnosed with peripheral T-cell lymphomas, either unspecified (PTCL-U, n=30) or angioimmunoblastic (AITL, n=20) were morphologically assessed for intra-tumoral eosinophilia and analyzed by immunohistochemistry using specific antibodies directed against TARC, IL-5, RANTES, and eotaxin. The AITL and PTCL-U cases contained a mean of 147+/-41 and 102+/-37 eosinophils per 10 high power fields, respectively. Thirty-two of 47 cases (68%) showed IL-5-positive lymphoma cells while 15/50 (30%) tumors showed variable staining for TARC in scattered non-lymphoid cells with dendritic morphology. TARC and IL-5-positive cases possessed significantly more eosinophils. Our data indicate that IL-5 and TARC expression highly correlate with eosinophilia in T-cell lymphomas, suggesting that these chemokines are involved in the recruitment of eosinophils into the tumors."xsd:string
http://purl.uniprot.org/citations/18395252http://purl.org/dc/terms/identifier"doi:10.1016/j.leukres.2008.02.016"xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/author"de Leval L."xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/author"Goldman M."xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/author"Boniver J."xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/author"Trimeche M."xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/author"Radermacher V."xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/author"Roufosse F."xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/author"Thielen C."xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/name"Leuk Res"xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/pages"1431-1438"xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/title"TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas."xsd:string
http://purl.uniprot.org/citations/18395252http://purl.uniprot.org/core/volume"32"xsd:string
http://purl.uniprot.org/citations/18395252http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18395252
http://purl.uniprot.org/citations/18395252http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18395252
http://purl.uniprot.org/uniprot/#_Q92583-mappedCitation-18395252http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18395252
http://purl.uniprot.org/uniprot/#_P05113-mappedCitation-18395252http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18395252
http://purl.uniprot.org/uniprot/P05113http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18395252
http://purl.uniprot.org/uniprot/Q92583http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18395252