http://purl.uniprot.org/citations/18396213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/18396213 | http://www.w3.org/2000/01/rdf-schema#comment | "Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the expansion of a PIG-A mutated hematopoietic stem cell. An immune-mediated origin has been suggested for this disease. Because HLA genes represent a susceptibility factor for autoimmunity, we investigated HLA genotype in 42 Italian PNH patients compared with 301 control subjects of the same ethnic origin. A significantly increased frequency of the HLA class I alleles A*0201 (p < 0.05), B*1402 (p < 0.001), and Cw*0802 (p < 0.005), and of the HLA class II DRB1*1501 (p < 0.01) with the linked DQB1*0602 (p = 0.05) and DRB1*01 (p = 0.05) with the linked DQB1*0501 (p = 0.01) alleles, has been observed. Notably, a fourfold increase of the haplotype B*1402, Cw*0802 (p < 0.0005) and a 15-fold increase of the Mediterranean haplotype A*33, B*1402, Cw*0802, DRB1*0102, DQB1*0501 (p < 0.005) was also revealed. This association may provide new insights into the autoimmune pathogenesis of PNH."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2008.02.001"xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Alfinito F."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Rotoli B."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Luzzatto L."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Poggi A."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Ruggiero G."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Pirozzi G."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Sica M."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Cosentini E."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Risitano A."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Lombardi M.L."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Gargiulo L."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Notaro R."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Terrazzano G."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Aufiero D."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/author | "Camerlingo R."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/pages | "202-206"xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/title | "Paroxysmal nocturnal hemoglobinuria: significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population."xsd:string |
http://purl.uniprot.org/citations/18396213 | http://purl.uniprot.org/core/volume | "69"xsd:string |
http://purl.uniprot.org/citations/18396213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18396213 |
http://purl.uniprot.org/citations/18396213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18396213 |