| http://purl.uniprot.org/citations/18396294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18396294 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuroinflammation and abnormal phosphorylation of TAU proteins have been implicated in the etiology of Alzheimer's disease (AD). Several studies have suggested the G-308A promoter polymorphism in one of the proinflammatory cytokine genes tumor necrosis factor-alpha (TNF-alpha) encoding TNF-alpha may be associated with AD pathogenesis. Association between the Q7R polymorphism in saitohin (STH), a gene nested within the intron of the Tau gene, has also been reported. To determine whether these two polymorphisms contribute to the risk for late-onset AD (LOAD) in Chinese, we have investigated 207 sporadic LOAD patients and 222 healthy controls. The associations of the AA genotype and A-allele with LOAD (chi(2) = 8.74, df = 1, P = 0.0031, and chi(2) = 4.47, df = 1, P = 0.035) were found. After stratifying by apolipoprotein E allele 4 (APOE epsilon4) status, increased LOAD risks associated with the AA genotype and A-allele only in the APOE epsilon4 non-carriers (chi(2) = 9.21, df = 1, P = 0.002; chi(2) = 10.02, df = 1, P = 0.0015) were seen. These results suggested that the TNF-alpha gene G-308A polymorphism might be a risk factor for LOAD and dependent on APOE epsilon4 status in Chinese. Homozygous Q/Q of STH Q7R polymorphism was the only one genotype found in either LOAD group or controls. No R allele was detected in LOAD and control groups. The extremely rare frequency of the ancestral R allele differs sharply from that observed in studies in the Caucasian population, suggesting obvious ethnic differences."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jns.2008.02.021"xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/author | "Zheng C."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/author | "Zhou S."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/author | "Lv Z."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/author | "Xie Y.C."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/name | "J Neurol Sci"xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/pages | "148-151"xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/title | "Genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G-308A and Saitohin Q7R polymorphisms with Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/18396294 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18396294 |
| http://purl.uniprot.org/citations/18396294 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18396294 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-18396294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18396294 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3B1-mappedCitation-18396294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18396294 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3V0-mappedCitation-18396294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18396294 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D5-mappedCitation-18396294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18396294 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3J5-mappedCitation-18396294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18396294 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X8M9-mappedCitation-18396294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18396294 |