| http://purl.uniprot.org/citations/18398001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18398001 | http://www.w3.org/2000/01/rdf-schema#comment | "In hair follicles, dermal papilla (DP) and dermal sheath (DS) cells exhibit striking levels of plasticity, as each can regenerate both cell types. Here, we show that thrombin induces a phosphoinositide 3-kinase (PI3K)-Akt pathway-dependent acquisition of DS-like properties by DP cells in vitro, involving increased proliferation rate, acquisition of ;myofibroblastic' contractile properties and a decreased capacity to sustain growth and survival of keratinocytes. The thrombin inhibitor protease nexin 1 [PN-1, also known as SERPINE2) regulates all those effects in vitro. Accordingly, the PI3K-Akt pathway is constitutively activated and expression of myofibroblastic marker smooth-muscle actin is enhanced in vivo in hair follicle dermal cells from PN-1(-/-) mice. Furthermore, physiological PN-1 disappearance and upregulation of the thrombin receptor PAR-1 (also known as F2R) during follicular regression in wild-type mice also correlate with such changes in DP cell characteristics. Our results indicate that control of thrombin signaling interferes with hair follicle dermal cells plasticity to regulate their function."xsd:string |
| http://purl.uniprot.org/citations/18398001 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.018689"xsd:string |
| http://purl.uniprot.org/citations/18398001 | http://purl.uniprot.org/core/author | "Barrandon Y."xsd:string |
| http://purl.uniprot.org/citations/18398001 | http://purl.uniprot.org/core/author | "Monard D."xsd:string |
| http://purl.uniprot.org/citations/18398001 | http://purl.uniprot.org/core/author | "Feutz A.C."xsd:string |
| http://purl.uniprot.org/citations/18398001 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18398001 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/18398001 | http://purl.uniprot.org/core/pages | "1435-1443"xsd:string |
| http://purl.uniprot.org/citations/18398001 | http://purl.uniprot.org/core/title | "Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells."xsd:string |
| http://purl.uniprot.org/citations/18398001 | http://purl.uniprot.org/core/volume | "121"xsd:string |
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