| http://purl.uniprot.org/citations/18398369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18398369 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeTo examine the retinal inflammatory response to ischemia-reperfusion in nondiabetic and diabetic rats injected with either an omega-3-polyunsaturated fatty acid (docosahexaenoic acid [DHA]) or a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (pravastatin).MethodsDiabetes was induced by an intraperitoneal injection of streptozocin, and retinal ischemia was induced by ligation of the optic nerve and vessels, followed by reperfusion for 1 hour or 24 hours. Five minutes before surgery, an intravenous injection of DHA, pravastatin, or vehicle (ethanol) was administered. The mRNA expressions of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, caspase-1, IL-1beta, P-selectin, vascular cellular adhesion molecule (VCAM)-1, and intercellular adhesion molecule (ICAM)-1 were compared between ischemic and nonischemic retinas as well as diabetic and nondiabetic nonischemic retinas.ResultsIschemia induced increased expressions of TNF-alpha (P ConclusionsInflammation triggered by ischemia-reperfusion may play a role in diabetic retinopathy. Intervention on lipid-based structures by omega-3-polyunsaturated fatty acids or statins seemed to have beneficial effects on inflammation in diabetes."xsd:string |
| http://purl.uniprot.org/citations/18398369 | http://purl.org/dc/terms/identifier | "doi:10.1097/iae.0b013e31815ec32d"xsd:string |
| http://purl.uniprot.org/citations/18398369 | http://purl.uniprot.org/core/author | "Agardh C.D."xsd:string |
| http://purl.uniprot.org/citations/18398369 | http://purl.uniprot.org/core/author | "Agardh E."xsd:string |
| http://purl.uniprot.org/citations/18398369 | http://purl.uniprot.org/core/author | "Gustavsson C."xsd:string |
| http://purl.uniprot.org/citations/18398369 | http://purl.uniprot.org/core/author | "Hagert P."xsd:string |
| http://purl.uniprot.org/citations/18398369 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18398369 | http://purl.uniprot.org/core/name | "Retina"xsd:string |
| http://purl.uniprot.org/citations/18398369 | http://purl.uniprot.org/core/pages | "645-652"xsd:string |
| http://purl.uniprot.org/citations/18398369 | http://purl.uniprot.org/core/title | "Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion."xsd:string |
| http://purl.uniprot.org/citations/18398369 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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