| http://purl.uniprot.org/citations/18400403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18400403 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously showed that intrathecal co-administration of amitriptyline with morphine upregulates the expression of the glial glutamate transporters glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) and restores neuronal glutamate transporter excitatory amino acid carrier 1 (EAAC1) expression in chronically morphine-infused rats. The present study examined the role of nuclear transcription factor-kappaB (NF-kappaB) in the regulation of the expression of GLAST, GLT-1, and EAAC1 following long-term amitriptyline/morphine co-infusion. Male Wistar rats were implanted with two intrathecal catheters with or without a microdialysis probe; one of the catheters was used for continuous infusion of saline (control), morphine (15 microg/h), or morphine plus amitriptyline (both 15 microg/h) for 5 days, while the other was used for a single daily intrathecal injection of the NF-kappaB inhibitor Ro106-9920 (10 microl of 10 microM) for 5 days. We found that amitriptyline co-infusion restored the antinociceptive effect of morphine (4.5-fold right-shift in the morphine dose-response curve compared with a 65-fold right-shift in its absence) and this effect was inhibited by Ro106-9920 administration (48-fold right-shift). Moreover, amitriptyline/morphine co-infusion increased IkappaBalpha phosphorylation and the translocation of NF-kappaB p65 from the cytosol to the nucleus. Daily intrathecal injection of Ro106-9920 prevented the amitriptyline/morphine-induced NF-kappaB p65 translocation and reversed the amitriptyline/morphine-induced GLAST and GLT-1 upregulation and inhibited the restoration of EAAC1 expression. The Ro106-9920 injections abolished the inhibitory effect of amitriptyline on the morphine-evoked release of excitatory amino acids into the spinal cerebrospinal fluid (CSF) dialysates. In conclusion, amitriptyline/morphine co-infusion restores the antinociceptive effect of morphine and upregulates GLAST and GLT-1 expression and restores EAAC1 expression to baseline levels, thus reducing excitatory amino acid levels in the spinal CSF dialysates. The mechanism involves activation of the NF-kappaB pathway, but may also involve other pathways."xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2008.02.055"xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/author | "Wang Y.H."xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/author | "Liu T.M."xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/author | "Wong C.S."xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/author | "Tai Y.H."xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/author | "Tsai R.Y."xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/author | "Tao P.L."xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/author | "Cherng C.H."xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/pages | "823-831"xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/title | "Amitriptyline induces nuclear transcription factor-kappaB-dependent glutamate transporter upregulation in chronic morphine-infused rats."xsd:string |
| http://purl.uniprot.org/citations/18400403 | http://purl.uniprot.org/core/volume | "153"xsd:string |
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