| http://purl.uniprot.org/citations/18400989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18400989 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca+ release-activated Ca2+ (CRAC) channels are activated when free Ca2+ concentration in the intracellular stores is substantially reduced and mediate sustained Ca2+ entry. Recent studies have identified Orai1 as a CRAC channel subunit. Here we demonstrate that passive Ca2+ store depletion using the inhibitor of the sarcoendoplasmic reticulum Ca2+-ATPase, thapsigargin (TG), enhances the surface expression of Orai1, a process that depends on rises in cytosolic free Ca2+ concentration, as demonstrated in cells loaded with dimethyl BAPTA, an intracellular Ca2+ chelator that prevented TG-evoked cytosolic free Ca2+ concentration elevation. Similar results were observed with a low concentration of carbachol. Cleavage of the soluble N-ethylmaleimide-sensitive-factor attachment protein receptor, synaptosomal-assiciated protein-25 (SNAP-25), with botulinum neurotoxin A impaired TG-induced increase in the surface expression of Orai1. In addition, SNAP-25 cleaving by botulinum neurotoxin A reduces the maintenance but not the initial stages of store-operated Ca2+ entry. In aggregate, these findings demonstrate that store depletion enhances Orai1 plasma membrane expression in an exocytotic manner that involves SNAP-25, a process that contributes to store-dependent Ca2+ entry."xsd:string |
| http://purl.uniprot.org/citations/18400989 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00071.2008"xsd:string |
| http://purl.uniprot.org/citations/18400989 | http://purl.uniprot.org/core/author | "Woodard G.E."xsd:string |
| http://purl.uniprot.org/citations/18400989 | http://purl.uniprot.org/core/author | "Rosado J.A."xsd:string |
| http://purl.uniprot.org/citations/18400989 | http://purl.uniprot.org/core/author | "Salido G.M."xsd:string |
| http://purl.uniprot.org/citations/18400989 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18400989 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/18400989 | http://purl.uniprot.org/core/pages | "C1323-31"xsd:string |
| http://purl.uniprot.org/citations/18400989 | http://purl.uniprot.org/core/title | "Enhanced exocytotic-like insertion of Orai1 into the plasma membrane upon intracellular Ca2+ store depletion."xsd:string |
| http://purl.uniprot.org/citations/18400989 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/18400989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18400989 |
| http://purl.uniprot.org/citations/18400989 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18400989 |
| http://purl.uniprot.org/uniprot/#_Q96D31-mappedCitation-18400989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18400989 |
| http://purl.uniprot.org/uniprot/Q96D31 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18400989 |