| http://purl.uniprot.org/citations/18402774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18402774 | http://www.w3.org/2000/01/rdf-schema#comment | "BAD, a member of the BCL2 family, exhibits an original mode of regulation by phosphorylation. In the present report, we examine the role of the kinase C-RAF in this process. We show that the inducible activation of C-RAF promotes the rapid phosphorylation of BAD on Serine-112 (Ser-75 in the human protein), through a cascade involving the kinases MEK and RSK. Our findings reveal a new aspect of the regulation of BAD protein and its control by the RAF pathway: we find that C-RAF activation promotes BAD poly-ubiquitylation in a phosphorylation-dependent fashion, and increases the turn-over of this protein through proteasomal degradation."xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.03.141"xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/author | "Becker M."xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/author | "Fischer A."xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/author | "Galmiche A."xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/author | "Fueller J."xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/author | "Hotz C."xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/author | "Sienerth A.R."xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/pages | "552-556"xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/title | "C-RAF activation promotes BAD poly-ubiquitylation and turn-over by the proteasome."xsd:string |
| http://purl.uniprot.org/citations/18402774 | http://purl.uniprot.org/core/volume | "370"xsd:string |
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