| http://purl.uniprot.org/citations/18406405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18406405 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanism/s leading to diabetic neuropathy are complex. Transforming growth factor-beta1 (TGF-beta1) has been associated with diabetic nephropathy and retinopathy but not neuropathy. In this study, changes in TGF-beta isoforms were examined in vivo and in vitro. Two groups of animals, streptozotocin diabetic with neuropathy and non-diabetic controls were examined at 4 weeks (n=10/group) and 12 weeks (n=8/group). In diabetic DRG using quantitative real-time PCR (QRT-PCR), TGF-beta1 and TGF-beta2 mRNA, but not TGF-beta3, was increased at 4 and 12 weeks. In sciatic nerve TGF-beta3 mRNA was primarily increased. Immunohistochemistry (DRG) and immunoblotting (sciatic nerve) showed similar differential protein expression. In sciatic nerve TGF-beta formed homo- and hetero-dimers, of which beta(2)/beta(3), beta(1)/beta(1), and beta(1)/beta(3) were significantly increased, while that of the TGF-beta(2)/beta(2) homodimer was decreased, in diabetic compared to non-diabetic rats. In vitro, pretreatment of embryonic DRG with TGF-beta neutralizing antibody prevents the increase in total TGF-beta protein observed with high glucose using immunoblotting. In high glucose conditions, combination with TGF-beta2>beta1 increases the percent of cleaved caspase-3 compared to high glucose alone and TGF-beta neutralizing antibody inhibits this increase. Furthermore, consistent with the findings in diabetic DRG and nerve, TGF-beta isoforms applied directly in vitro reduce neurite outgrowth, and this effect is partially reversed by TGF-beta neutralizing antibody. These findings implicate upregulation of TGF-beta in experimental diabetic peripheral neuropathy and indicate a novel mechanism of cellular injury related to elevated glucose levels. In combination, these findings indicate a potential new target for treatment of diabetic peripheral neuropathy."xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.expneurol.2008.02.011"xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/author | "Anjaneyulu M."xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/author | "Russell J.W."xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/author | "Berent-Spillson A."xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/author | "Cherian K."xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/name | "Exp Neurol"xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/pages | "469-479"xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/title | "Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy."xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://purl.uniprot.org/core/volume | "211"xsd:string |
| http://purl.uniprot.org/citations/18406405 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18406405 |
| http://purl.uniprot.org/citations/18406405 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18406405 |
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