| http://purl.uniprot.org/citations/18413740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18413740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18413740 | http://www.w3.org/2000/01/rdf-schema#comment | "In a previous genomic analysis, using somatic methyltransferase (DNMT) knockout cells, we showed that hypomethylation decreased the expression of as many genes as were observed to increase, suggesting a previously unknown mechanism for epigenetic regulation. To address this idea, the expression of the BAG family genes was used as a model. These genes were used because their expression was decreased in DNMT1(-/-), DNMT3B(-/-), and double knockout cells and increased in DNMT1-overexpressing and DNMT3B-overexpressing cells. Chromatin immunoprecipitation analysis of the BAG-1 promoter in DNMT1-overexpressing or DNMT3B-overexpressing cells showed a permissive dimethyl-H3-K4/dimethyl-H3-K9 chromatin status associated with DNA-binding of CTCFL/BORIS, as well as increased BAG-1 expression. In contrast, a nonpermissive dimethyl-H3-K4/dimethyl-H3-K9 chromatin status was associated with CTCF DNA-binding and decreased BAG-1 expression in the single and double DNMT knockout cells. BORIS short hairpin RNA knockdown decreased both promoter DNA-binding, as well as BAG-1 expression, and changed the dimethyl-H3-K4/dimethyl-H3-K9 ratio to that characteristic of a nonpermissive chromatin state. These results suggest that DNMT1 and DNMT3B regulate BAG-1 expression via insulator protein DNA-binding and chromatin dynamics by regulating histone dimethylation."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-6654"xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-6654"xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Nguyen P."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Nguyen P."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Cui H."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Cui H."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Feinberg A.P."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Feinberg A.P."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Bradbury C.M."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Bradbury C.M."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Gius D."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Gius D."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Bar-Sela G."xsd:string |
| http://purl.uniprot.org/citations/18413740 | http://purl.uniprot.org/core/author | "Bar-Sela G."xsd:string |