| http://purl.uniprot.org/citations/18414472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18414472 | http://www.w3.org/2000/01/rdf-schema#comment | "The Fanconi gene family has a role in DNA repair and inactivation of FANCF has been proposed as a mechanism of sensitisation to platinum chemotherapy. This study sought to confirm this hypothesis in cell lines and a large series of ovarian cancer samples. Promoter methylation was assessed by methylation-sensitive polymerase chain reaction of FANCF in nine ovarian cancer cell lines and 74 ovarian cancer samples taken from patients entered on a trial of cisplatin-based chemotherapy. This study confirmed methylation-dependent silencing of FANCF in one out of nine ovarian cancer cell lines. Methylation of FANCF was demonstrated in 13.2% of 53 evaluable ovarian tumour samples. Progression-free survival gave an HR of 3.63 (95% CI: 1.54-8.54, P=0.0016) in favour of the unmethylated cases. There was no association with overall survival. This study does not support methylation-dependent silencing of FANCF as a mechanism of sensitisation to platinum-based chemotherapy in ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.bjc.6604325"xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/author | "Smith P."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/author | "Crook T."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/author | "van der Burg M."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/author | "Wong H."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/author | "Syed N."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/author | "Lim S.L."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/author | "Green J.A."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/author | "Coens C."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/author | "Szlosarek P."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/name | "Br J Cancer"xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/pages | "1452-1456"xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/title | "Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/18414472 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18414472 |
| http://purl.uniprot.org/citations/18414472 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18414472 |
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| http://purl.uniprot.org/uniprot/Q6MZN0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18414472 |
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