| http://purl.uniprot.org/citations/18419598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18419598 | http://www.w3.org/2000/01/rdf-schema#comment | "Transferrin and transferrin receptor are two key proteins of iron metabolism that have been identified to be hypoxia-inducible genes. Divalent metal transporter 1 (DMT1) is also a key transporter of iron under physiological conditions. In addition, in the 5' regulatory region of human DMT1 (between -412 and -570), there are two motifs (CCAAAGTGCTGGG) that are similar to hypoxia-inducible factor-1 (HIF-1) binding sites. It was therefore speculated that DMT1 might also be a hypoxia-inducible gene. We investigated the effects of hypoxia and hypoxia/re-oxygenation on the expression of DMT1 and the content of HIF-1alpha in HepG2 cells. As we expected, a very similar tendency in the responses of the expression of HIF-1alpha, DMT1+IRE (iron response element) and DMT1-IRE proteins to chemical (CoCl(2)) or physical hypoxia was observed. A highly significant correlation was found between the expression of DMT1 proteins and the contents of HIF-1 in hypoxic cells. After the cells were exposed to hypoxia and subsequent normoxia, no HIF-1alpha could be detected and a significant decrease in DMT1+IRE expression (P<0.05), but not in DMT1-IRE protein (versus the hypoxia group), was observed. The findings implied that the HIF-1 pathway might have a role in the regulation of DMT1+IRE expression during hypoxia."xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1582-4934.2007.00145.x"xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/author | "Lai Z."xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/author | "Lei Y."xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/author | "Fang D."xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/author | "Ho Y.W."xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/author | "Ming Q.Z."xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/author | "Ya K."xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/pages | "569-579"xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/title | "Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells."xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/18419598 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18419598 |
| http://purl.uniprot.org/citations/18419598 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18419598 |
| http://purl.uniprot.org/uniprot/Q16665#attribution-CCB3F197D9CE0F59B578D250A67535CE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18419598 |
| http://purl.uniprot.org/uniprot/P49281#attribution-AB9703EAF5997A8B0D4BB4E78BEEFA58 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18419598 |
| http://purl.uniprot.org/uniprot/P49281#attribution-CCB3F197D9CE0F59B578D250A67535CE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18419598 |
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| http://purl.uniprot.org/uniprot/#_A0A0X8GKR4-mappedCitation-18419598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18419598 |