| http://purl.uniprot.org/citations/18422486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18422486 | http://www.w3.org/2000/01/rdf-schema#comment | "Background informationPrecise localization of proteins to specialized subcellular domains is fundamental for proper neuronal development and function. The neural microtubule-regulatory phosphoproteins of the stathmin family are such proteins whose specific functions are controlled by subcellular localization. Whereas stathmin is cytosolic, SCG10, SCLIP and RB3/RB3'/RB3'' are localized to the Golgi and vesicle-like structures along neurites and at growth cones. We examined the molecular determinants involved in the regulation of this specific subcellular localization in hippocampal neurons in culture.ResultsWe show that their conserved N-terminal domain A carrying two palmitoylation sites is dominant over the others for Golgi and vesicle-like localization. Using palmitoylation-deficient GFP (green fluorescent protein) fusion mutants, we demonstrate that domains A of stathmin proteins have the particular ability to control protein targeting to either Golgi or mitochondria, depending on their palmitoylation. This regulation involves the co-operation of two subdomains within domain A, and seems also to be under the control of its SLD (stathmin-like domain) extension.ConclusionsOur results unravel that, in specific biological conditions, palmitoylation of stathmin proteins might be able to control their targeting to express their functional activities at appropriate subcellular sites. They, more generally, open new perspectives regarding the role of palmitoylation as a signalling mechanism orienting proteins to their functional subcellular compartments."xsd:string |
| http://purl.uniprot.org/citations/18422486 | http://purl.org/dc/terms/identifier | "doi:10.1042/bc20070119"xsd:string |
| http://purl.uniprot.org/citations/18422486 | http://purl.uniprot.org/core/author | "Chauvin S."xsd:string |
| http://purl.uniprot.org/citations/18422486 | http://purl.uniprot.org/core/author | "Poulain F.E."xsd:string |
| http://purl.uniprot.org/citations/18422486 | http://purl.uniprot.org/core/author | "Sobel A."xsd:string |
| http://purl.uniprot.org/citations/18422486 | http://purl.uniprot.org/core/author | "Ozon S."xsd:string |
| http://purl.uniprot.org/citations/18422486 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18422486 | http://purl.uniprot.org/core/name | "Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/18422486 | http://purl.uniprot.org/core/pages | "577-589"xsd:string |
| http://purl.uniprot.org/citations/18422486 | http://purl.uniprot.org/core/title | "Palmitoylation of stathmin family proteins domain A controls Golgi versus mitochondrial subcellular targeting."xsd:string |
| http://purl.uniprot.org/citations/18422486 | http://purl.uniprot.org/core/volume | "100"xsd:string |
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